This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Family Smoking Prevention and Tobacco Control Act Regulatory Research program (CFDA 93.077) provides $370,000 to the Marshall University Research Corporation (MURC) in Huntington, West Virginia. The grant's objective is to determine the impact of synthetic coolants on nicotine's abuse liability and initiation-related behaviors. The research will utilize a novel vapor self-administration assay in mice to examine how synthetic coolants affect nicotine reinforcement, nicotinic acetylcholine receptor (nAChR) upregulation, and neurophysiology. This work aims to establish a scientific foundation to inform future regulatory actions regarding synthetic coolants and their public health implications. The project will be conducted over a 5-year period from February 1, 2025 to January 31, 2030.
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