Project Grant R01CA315976
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Research Foundation for the State University of New York $410,545 under the Cancer Treatment Research program (CFDA 93.395) for a two-year project period from May 1, 2026, through April 30, 2028. This project grant supports research to assess efflux transport mechanisms, pharmacokinetics, and systems pharmacology impacts on monomethyl auristatin E (MMAE)-induced neurotoxicity in patients receiving antibody-drug conjugate...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $323,860 Project Grant on August 18, 2025, to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) to support biomedical research training and investigator development in cancer science. The project, titled "Investigating the Role of Mutagenic DNA Repair During the Persistence of Cancer Cells," will be conducted at the Institute's New York facility through April...
- Federal Grant Award Summary The National Cancer Institute awarded Icahn School of Medicine at Mount Sinai a $683,256 Project Grant under the Cancer Biology Research program (CFDA 93.396) on May 22, 2026, with a completion date of April 30, 2031. This award funds research to develop a human-mouse platform for data-driven patient stratification, target discovery, and validation in glioblastoma (GBM). The project addresses the critical clinical challenge of GBM's high inter- and intra-tumor...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Columbia University a $702,132 Project Grant on June 11, 2026, under the Cancer Treatment Research program (CFDA 93.395) to conduct multiplex single-cell chemical genomics research aimed at identifying small molecule modulators of tumor cell-intrinsic immunogenicity in glioblastoma. The three-year research initiative, concluding May 31, 2029, will employ highly multiplex chemical transcriptomic profiling to screen 3,792...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Sloan-Kettering Institute for Cancer Research a $3.2 million Project Grant under the Cancer Cause and Prevention Research program (CFDA 93.393) beginning August 1, 2025, and concluding July 31, 2029. This research initiative investigates the mechanisms of extrachromosomal DNA (ecDNA) segregation and repair in cancer cells, with emphasis on understanding how ecDNA's circular topology contributes to tumor progression...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $681,818 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Cancer Treatment Research program (CFDA 93.395) for the period June 2, 2026 through May 31, 2031. The research focuses on restoring anti-tumor immunity in chromosomally unstable tumors through investigation of the cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) signaling pathway. The...
- Federal Grant Award Summary Georgetown University received a $656,469 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective June 1, 2026, with completion targeted for May 31, 2031. The research focuses on elucidating the role of the ZDHHC3-PRPS1 (Phosphoribosyl Pyrophosphate Synthetase) regulatory axis in de novo nucleotide synthesis and glioblastoma (GBM) response to radiochemotherapy. The project investigates how ZDHHC3 governs...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $642,242 under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on the mechanisms of breast cancer brain metastasis. The five-year project, which commenced May 15, 2026 and concludes April 30, 2031, will investigate the function and therapeutic implications of Neuregulin 3 (NRG3) in facilitating the transition of breast cancer...
- Federal Project Grant Award Summary The National Cancer Institute awarded $292,028 to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) beginning August 1, 2025, and concluding July 31, 2030. This five-year Project Grant supports research investigating genome instability associated with focal oncogene amplification (OA) and the development of therapeutic strategies to address treatment-resistant cancers. The research deliverables include...
The National Cancer Institute (NCI) awarded a $532,553 Project Grant to The Research Foundation For The State University of New York, doing business as Stony Brook University, under the Cancer Cause and Prevention Research program (CFDA 93.393). The award, effective July 1, 2026 through June 30, 2031, supports research investigating the repair of temozolomide (TMZ)-induced DNA damage in transcribed genes. This five-year research initiative focuses on understanding how TMZ adducts interfere with RNA polymerase II (RNAP) progression and gene transcription in glioblastoma (GBM) cells, with particular emphasis on the role of transcription-coupled nucleotide excision repair (TC-NER) pathways in resolving drug-induced damage and contributing to cancer cell resistance. The research deliverables include characterization of RNAP arrest mechanisms caused by TMZ damage, genome-wide damage mapping using novel NMP-SEQ sequencing techniques, and analysis of The Cancer Genome Atlas (TCGA) data to identify mutational patterns and strand asymmetry in TMZ-treated GBM tumors. The project aims to elucidate how TC-NER factors facilitate recovery from transcriptional blockages and to evaluate TC-NER as a potential pharmaceutical target for enhancing TMZ sensitivity in GBM treatment. Findings from this research are expected to advance understanding of alkylation damage repair mechanisms and inform strategies to overcome drug resistance in brain cancer therapy.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $532.6k | 6/17/26 |