Project Grant R01CA311805
- Federal Project Grant Award Summary Children's Hospital Los Angeles received an $8.47 million Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded September 10, 2025, with a completion date of August 31, 2029. The grant funds a patient navigation intervention designed to improve transition success among multiply disadvantaged young adult survivors of childhood cancer (CCS). The project addresses a critical gap in...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $530,106 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective September 11, 2025 through August 31, 2030. The project, "Targeting Polyamine Metabolism in Relapsed Acute Myeloid Leukemia Stem Cells," focuses on fundamental research to understand and mechanistically interrogate polyamine metabolism in leukemia stem cells (LSCs). The...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $901,205 to Boston Children's Hospital under the Cancer Treatment Research program (CFDA 93.395) effective July 3, 2025, with a completion date of June 30, 2032. This research initiative focuses on identifying genome-wide changes in gene expression during early tumorigenesis and metastatic progression to improve immunotherapy efficacy. The project leverages genetically engineered mouse models...
- Federal Project Grant Award Summary Boston Children's Hospital received a $679,604 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective August 1, 2025 through July 31, 2030. The grant supports fundamental research investigating pathways involved in melanoma initiation and formation using zebrafish genetic models. Research activities include studying melanocyte-specific expression of oncogenic mutations, identifying and...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $2.097 million Project Grant to the University of California, Los Angeles under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period September 1, 2025 through August 31, 2029. The award supports translational development of an extracellular vesicle (EV) matrix metalloproteinase (MMP) activity assay designed to assess patient treatment responses in osteosarcoma, the most common pediatric bone...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration within the School of Medicine a Project Grant totaling $109,076.00 under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025. The award supports biomedical research training and career development initiatives focused on cancer research through September 1, 2029. This project grant funds the institution's capacity to provide integrated...
- Federal Grant Award Summary The National Cancer Institute awarded Seattle Children's Hospital (doing business as Seattle Children's Research Institute) a $3.48 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2029. This project systematically identifies genomic heterogeneity and relapse predictors in pediatric and adolescent/young adult patients with Philadelphia chromosome-positive (PH+) and ABL-class PH-like acute...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Children's Hospital of Philadelphia Research Institute a project grant of $197,518.00, effective September 8, 2025, through August 31, 2030, under the Cancer Treatment Research program (CFDA 93.395). This funding supports the development of rare tumor clinical research infrastructure and trial capacity within the Children's Oncology Group (COG) and the National Clinical Trials Network (NCTN). The principal...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $608,558 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Research Institute at Nationwide Children's Hospital, effective April 2, 2026, through March 31, 2031. This fundamental cancer research initiative aims to advance understanding of high-risk neuroblastoma through the development of clinically relevant immunocompetent mouse models and the identification of metabolic vulnerabilities that can...
Children's Hospital Los Angeles received a $573,286 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 5, 2026 through April 1, 2031. This research initiative aims to elucidate inter-compartmental tumor-host communication mechanisms driving early dissemination in uveal melanoma (UM), a rare ocular malignancy with high propensity for hepatic metastasis. The project delivers comprehensive mechanistic research through three coordinated aims: (1) examination of how high-risk tumor features shape the local ocular microenvironment; (2) characterization of systemic plasma signal changes originating from primary tumors; and (3) analysis of rare circulating cells and cross-compartment signaling patterns using advanced imaging technologies. The research products will be generated from a prospective, longitudinal cohort of over 100 newly diagnosed UM patients, with multi-timepoint sampling from tumor tissue, aqueous humor, plasma, and peripheral blood. Deliverables include integrated biomarker analyses of extracellular vesicles, soluble proteins, and circulating cell populations, culminating in the definition of tumor-host communication "states" predictive of early metastatic spread. These findings are designed to provide the scientific foundation for future clinical monitoring strategies and early intervention approaches for high-risk UM patients, addressing a significant gap in understanding metastatic progression in this rare cancer type.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $573.3k | 5/7/26 |