Project Grant R01CA310862
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a five-year Project Grant totaling $639,514 to The University of Texas Southwestern Medical Center (UT Southwestern) under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026, through May 31, 2031. The award supports fundamental cancer biology research focused on characterizing the catalytic mechanisms of NVL (a nucleolar AAA+ adenosine triphosphatase) inhibition by benzothiazepinone...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Texas MD Anderson Cancer Center a $473,372 project grant under the Cancer Biology Research program (CFDA 93.396) to investigate proline transfer ribonucleic acid (tRNA) biogenesis as an oncogenic driver and therapeutic target in T cell acute lymphoblastic leukemia (T-ALL). The research project, initiated April 8, 2026 and extending through March 31, 2031, will deliver mechanistic studies examining how...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Beckman Research Institute of the City of Hope a $517,090 Project Grant under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, to investigate the role and biological function of a novel signature gene designated AL021978.1 (A978) in Philadelphia chromosome (PH)-positive and PH-like B-cell acute lymphoblastic leukemia (B-ALL). The research aims to address high-risk leukemia subtypes with survival...
- Federal Grant Award Summary Baylor College of Medicine received a $160,500 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective July 10, 2025, with completion targeted for June 30, 2027. The award funds the development and investigation of in vivo murine models to examine the role of caspase-2 in nucleophosmin-mutated acute myeloid leukemia (NPM1C+ AML). The research deliverables include the establishment of transgenic mouse...
- Federal Grant Award Summary The National Cancer Institute awarded a $404,972 Project Grant to The University of Texas Health Science Center at San Antonio under the Cancer Biology Research program (CFDA 93.396) for a two-year project period beginning August 1, 2025 and concluding July 31, 2027. This award supports fundamental research investigating ribosomal ribonucleic acid (rRNA) modification, ribosome composition, and specialized translation mechanisms in glioblastoma, the most common and...
- Federal Grant Award Summary Baylor College of Medicine received a $2.4 million Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective August 15, 2025 through July 31, 2029. The award funds research investigating the role of RNA sequestration in acute myeloid leukemia (AML), specifically examining how the RNA helicase DDX6 (DEAD-Box Helicase 6) regulates post-transcriptional processes critical to leukemia development and...
- This $683,472 Project Grant from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) supports research by the University of Cincinnati to develop a novel targeted therapy for acute myeloid leukemia (AML). The key objectives are to therapeutically target the DHODH enzyme to induce AML cell differentiation, activate the immune system, and induce ferroptosis-mediated cell death. This approach aims to better differentiate AML cells from normal hematopoietic stem cells and enhance...
- Grant Award Summary Cincinnati Children's Hospital Medical Center received a $530,106 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded September 11, 2025, with completion by August 31, 2030. The research project targets polyamine metabolism in leukemia stem cells (LSCs) to develop therapeutic interventions for acute myeloid leukemia (AML). The project delivers fundamental research investigating the mechanistic role of...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $415,259 to the Rector & Visitors of the University of Virginia to conduct research on the role of long noncoding RNAs in acute myeloid leukemia (AML). The project aims to 1) determine the role of a specific regulatory RNA in primary and relapsed AML, and 2) define the mechanism underlying its deregulation in AML. This research will provide insights into how noncoding RNAs...
- This five-year $360,281 Project Grant from the National Cancer Institute, part of the Department of Health and Human Services, will fund research under the Cancer Biology Research program (CFDA 93.396). The grantee, Washington University, will conduct studies to define the contribution of altered epigenetic patterns and genome organization to the pathogenesis of acute myeloid leukemia (AML). Researchers will perform comprehensive epigenetic analysis of DNA methylation and three-dimensional...
The National Cancer Institute awarded a $544,988 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas Health Science Center at San Antonio beginning June 1, 2026, through May 31, 2031. This five-year research project will investigate the molecular mechanisms underlying PHF6 (Plant Homeodomain Finger protein 6) mutations in hematologic malignancies, including T-cell acute lymphoblastic leukemia (T-ALL), mixed phenotype acute leukemia (MPAL), acute myeloid leukemia (AML), chronic myelomonocytic leukemia (CMML), and myelodysplastic syndrome (MDS). The research will utilize patient-derived transgenic mouse models expressing truncated PHF6 proteins to decipher the gain-of-function mechanisms by which PHF6 mutations contribute to leukemogenesis, with the ultimate goal of identifying therapeutic vulnerabilities and advancing cancer prevention, detection, and treatment methodologies. This fundamental research project directly supports the Cancer Biology Research program's objective to provide essential information on cancer's cause and nature through investigation of DNA and chromosomal aberrations, cancer cell biology, and cancer immunology and hematology. The award will be performed at UTHSCSA's San Antonio, Texas facility, leveraging the institution's established expertise in biomedical research and cancer studies to advance understanding of molecularly driven hematologic malignancy development.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $545.0k | 5/26/26 |