Project Grant R01CA310177
- Federal Grant Award Summary Oregon Health & Science University received a $625,179 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded on March 26, 2026, with completion targeted for February 28, 2031. The award funds research aimed at developing direct and indirect targeting strategies of the MCL1 (myeloid cell leukemia-1) protein to improve therapeutic outcomes for osteosarcoma patients with lung metastasis. The...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Oregon Health & Science University a $2.27 million Project Grant under the Cancer Biology Research program (CFDA 93.396) on September 23, 2025, with completion targeted for August 31, 2029. This award supports fundamental research investigating androgen receptor (AR) signaling in conventional dendritic cells (CDCs) and its role in sex-based differences in anti-tumor immune function, particularly in melanoma....
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $1.39 million Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective July 1, 2025, through March 31, 2030. The award funds development of an organ-on-a-chip model to investigate oral squamous cell carcinoma (OSCC) invasion into bone tissue. This in vitro research platform replicates the complex...
- Federal Grant Award Summary Oregon Health & Science University received a $356,850 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026 through March 31, 2031. The award supports research to develop and evaluate improved cancer treatment methods through the discovery, development, and clinical testing of novel therapeutic approaches. Specifically, the research targets Y-Box Binding Protein 1 (YB-1)...
- Federal Grant Award Summary Oregon Health & Science University received a $662,913 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective August 1, 2025, through July 31, 2029. The research focuses on developing a peptide amphiphile (PA)-based universal drug delivery platform designed to address significant limitations of...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $109,076 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective January 16, 2026, with an ultimate completion date of July 15, 2029. The grant supports biomedical research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. OHSU will conduct research investigating the...
- Federal Project Grant Award Summary Oregon Health & Science University received a $2.49 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) on August 15, 2025, with a completion date of July 31, 2029. The award supports development and validation of fluorescence-guided surgery (FGS) technology to enable real-time nerve visualization during colorectal cancer surgical procedures. The project addresses a...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $483,343.83 to the University of New Mexico Health Sciences Center on May 7, 2025, under the Cancer Biology Research program (CFDA 93.396) to support fundamental research on the regulation of ovarian cancer metastasis. The research project, which extends through November 30, 2030, investigates how microenvironmental signals activate the transcription factor C-JUN in ovarian cancer cells and...
- Federal Grant Award Summary Oregon Health & Science University (OHSU) received a $390,000 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 1, 2026, with a completion date of March 31, 2031. The award funds a multi-scale and multi-modal computational modeling research initiative titled "Multi-Scale and Multi-Modal Computational Modeling of Cell State Plasticity and Drug...
- Grant Award Summary The National Cancer Institute (NCI) awarded a $450,904 Project Grant to the Pacific Northwest National Laboratory (PNNL), a division of Battelle Memorial Institute, under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. The funded project will develop a novel single-cell (phospho-)proteomics platform designed to characterize tumor microenvironment (TME) components—including cancer cells, immune cells, and stromal...
The National Cancer Institute awarded Oregon Health & Science University (OHSU) a Project Grant totaling $521,002 under the Cancer Biology Research program (CFDA 93.396) on March 26, 2026, with a completion date of February 28, 2031. This award funds the development and application of a microphysiological bone metastasis-on-a-chip platform designed to advance understanding of prostate cancer metastasis to bone tissue. The research deliverables include an innovative organ-on-chip system incorporating a mineralized, osteocyte-embedded bone matrix with active osteoclast/osteoblast remodeling capabilities, perfusable pericyte-supported vasculature to study circulating tumor cell extravasation dynamics, and integrated neural networks to investigate tumor-nerve crosstalk. These technological products will support two primary research aims: characterizing how bone-specific vascular mechanics orchestrate circulating tumor cell extravasation and osteolytic destruction through high-resolution live imaging and single-cell genomic/epigenetic analyses, and elucidating the role of neural components in metastatic niche formation through bidirectional tumor-nerve signaling studies. The anticipated research outputs will provide fundamental insights into the biological mechanisms governing prostate cancer bone metastasis, which occurs in over 80% of advanced cases and causes serious skeletal complications. By recapitulating critical microenvironmental features absent in existing models—including functional vascular networks, innervation, and controlled nanoscale mineralization—this project is expected to advance the field's understanding of metastatic colonization and potentially identify new therapeutic vulnerabilities relevant to cancer prevention and treatment development.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $521.0k | 3/31/26 |