Project Grant R01CA309542
- Federal Grant Award Summary The National Cancer Institute awarded The Children's Hospital of Philadelphia Research Institute a $457,683 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, through March 31, 2028. This research initiative focuses on developing and optimizing macromolecular prodrug-based drug delivery systems to enhance the efficacy of SN-38 (a topoisomerase I inhibitor) against high-risk neuroblastoma, the most common and deadly solid...
- Federal Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $197,518 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective September 8, 2025, through August 31, 2030. This award supports the development of a Rare Tumor Clinical Research Specialist position focused on addressing critical barriers in clinical research for rare cancers, which collectively account for 25% of cancer deaths despite...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Cincinnati Children's Hospital Medical Center a $1.48M Project Grant on September 1, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and evaluate SUMMIT (Supporting Medication Management with Individualized Treatment), a tailored medication adherence-promotion intervention designed specifically for adolescents and young adults (AYAs) with cancer. The five-year award, extending through...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Ann & Robert H Lurie Children's Hospital of Chicago a $651,859 Project Grant on September 19, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and evaluate #AYAOSM (The AYA Oncology Self-Care Movement), an influencer-driven social media intervention designed to improve oral chemotherapy adherence in adolescents and young adults (AYAs) with acute lymphoblastic leukemia. Prior...
- Federal Grant Award Summary Children's Hospital Los Angeles received an $8.47 million Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded on September 10, 2025, with completion targeted for August 31, 2029. The grant supports development and implementation of a health-related social needs (HRSN)-informed patient navigator intervention designed to improve transition success from pediatric to adult-focused survivorship...
- Federal Project Grant Award Summary The Research Institute at Nationwide Children's Hospital received a $406,258 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period May 1, 2026 through April 30, 2028. The award supports MEDMEMOS, a novel adherence promotion intervention designed to improve medication management in pediatric allogeneic hematopoietic stem cell transplantation (PAHCT) patients. The primary...
- Federal Grant Award Summary The National Cancer Institute awarded The Children's Hospital of Philadelphia a Project Grant totaling $737,082 (awarded May 13, 2026; completion April 30, 2031) under the Cancer Treatment Research program (CFDA 93.395) to develop bioinspired virus-like nanovaccines designed to enhance chimeric antigen receptor (CAR) T cell therapy and endogenous T cell responses against solid tumors with antigen heterogeneity. The project will produce an autologous tumor cell...
- Federal Grant Award Summary The National Cancer Institute awarded Seattle Children's Hospital (doing business as Seattle Children's Research Institute) a $3.48 million Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2029. This project systematically identifies genomic heterogeneity and relapse predictors in pediatric and adolescent/young adult patients with Philadelphia chromosome-positive (PH+) and ABL-class PH-like acute...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $901,205 to Boston Children's Hospital under the Cancer Treatment Research program (CFDA 93.395) effective July 3, 2025, with a completion date of June 30, 2032. This research initiative focuses on identifying genome-wide changes in gene expression during early tumorigenesis and metastatic progression to improve immunotherapy efficacy. The project leverages genetically engineered mouse models...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $105,076 Project Grant under the Cancer Research Manpower program (CFDA 93.398) on February 15, 2026, with completion targeted for August 14, 2027. This award supports a multi-method research study investigating the quality of electronic communication (e-communication) between parental caregivers of children with cancer and their healthcare teams. The research applies Relational...
The National Cancer Institute (NCI) awarded The Children's Hospital of Philadelphia $749,133 in project grant funding (CFDA 93.393: Cancer Cause and Prevention Research) effective June 1, 2026, through May 31, 2031, to develop and evaluate DECIDES 2.0, an enhanced decision support intervention for adolescents and young adults (AYA) ages 15-24 newly diagnosed with cancer. The primary deliverable is a randomized controlled trial (RCT) testing the efficacy of DECIDES 2.0—an upgraded interactive mobile-friendly web-based tool with accompanying text message functionality, Spanish language version, and delivery proximate to diagnosis. The intervention supports shared treatment-related decision-making among AYA, their caregivers, and oncology clinicians at three pediatric cancer centers, enrolling 250 AYA participants within four weeks of diagnosis. The project addresses a critical gap in cancer care by enabling AYA participation in treatment decisions—including initial decisions regarding treatment selection and clinical trial enrollment, as well as ongoing decisions regarding treatment modifications and supportive care management. DECIDES 2.0 is designed to improve documented short-term outcomes such as reduced decision regret and increased clinical trial participation, as well as longer-term outcomes including enhanced self-management skills and medication adherence. The intervention directly supports the NCI's Cancer Cause and Prevention Research program objectives by advancing health-related quality of life and patient-centered outcomes in cancer care delivery.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $749.1k | 5/26/26 |