Project Grant R01CA308211
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Rutgers The State University of New Jersey, Robert Wood Johnson Medical School (RBHS-School of Nursing) a $170,930 project grant under the Cancer Biology Research program (CFDA 93.396) effective April 1, 2026, through March 31, 2028. This research project investigates the longitudinal dynamics of blood microbiome composition and circulating tumor cells (CTCs) in metastatic breast cancer patients, with particular...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $375,150 to The Regents of the University of California, San Francisco under the Cancer Treatment Research program (CFDA 93.395) to fund a five-year research initiative (September 1, 2025 – August 31, 2030). The research addresses innate resistance mechanisms to KRAS inhibitors in cancer treatment, focusing on the role of the RhoA-ROCK-Myosin IIA cytoskeletal axis in promoting drug-tolerant persister...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a $657,776 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning August 1, 2025, and extending through May 31, 2030. This award supports the development of highly tumor-selective pan RAS inactivators to address oncogenic RAS-driven cancers, which account for approximately 46% of all human malignancies. The project addresses a significant clinical challenge: while...
- Federal Grant Award Summary Rutgers The State University of New Jersey, Robert Wood Johnson Health Sciences (RBHS)-School of Nursing received a $403,689 Project Grant award from the National Cancer Institute (NCI) effective August 1, 2025, through July 31, 2027, under the Cancer Cause and Prevention Research program (CFDA 93.393). The grant funds research investigating the influence of menthol cigarette smoking on lung cancer screening eligibility within a national prospective cohort study....
- Federal Grant Award Summary New York University School of Medicine received a $435,827 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective June 4, 2025, with completion targeted for May 31, 2027. The grant supports research entitled "Exploiting Synthetic Lethality to Enhance KRAS Inhibitor Therapy of Cancer," which investigates combination therapeutic strategies to overcome intrinsic and emergent resistance to...
- Federal Project Grant Award Summary Rutgers The State University of New Jersey (RBHS-School of Nursing) received a $197,414 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) on August 7, 2025, with completion targeted for July 31, 2030. This award supports a K01 (Mentored Research Development) grant designed to develop an early-career investigator's research capacity and expertise in studying dyadic and social network influences...
- Federal Grant Award Summary The National Cancer Institute awarded a $730,398 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) beginning April 1, 2026, and extending through March 31, 2031. This award supports research investigating tumor regenerative cell (TRC) populations that drive resistance to neoadjuvant therapy and metastatic recurrence in locally advanced rectal cancer (LARC). The research deliverables include genomic...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a $682,673 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective May 1, 2026, with completion targeted for April 30, 2031. This five-year award supports research into the adaptation and evolution of resistance to pan-RAS inhibition in pancreatic ductal adenocarcinoma (PDAC), a disease that claims over 52,000 lives annually in the United...
- Federal Grant Award Summary Rutgers, The State University of New Jersey, through its Cancer Institute of New Jersey, received a $768,420 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) effective July 1, 2025, through June 30, 2028. The award funds research investigating the rewiring of very long chain fatty acid metabolism in pancreatic tumor-associated macrophages to overcome KRAS-targeted therapy resistance. This...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $399,129 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on July 15, 2025, with a completion date of June 30, 2027. This award supports research to develop and evaluate improved cancer treatment methods through laboratory and clinical investigation. Specifically, the research leverages a DDX3 inhibitor called RK-33 to alter the metabolic tumor environment in...
Rutgers The State University of New Jersey received a $516,808 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective June 1, 2026 through May 31, 2031. The award supports fundamental research to elucidate the mechanism of targeting methionine synthase (MTR) to enhance anti-tumor immunity in KRAS-driven non-small cell lung cancer (NSCLC). The research addresses the critical clinical challenge of KRAS-driven NSCLC patient resistance to immune checkpoint blockade (ICB) therapy by investigating how targeting MTR—a key enzyme in one-carbon metabolism—can overcome tumor immune evasion and improve treatment efficacy. The funded research will advance understanding of how MTR depletion suppresses tumor growth through immune-mediated mechanisms, building upon preliminary findings demonstrating that MTR knockout increases tumor CD8 T cell infiltration and extends survival in genetically engineered mouse models of KRAS-driven lung cancer. This work will support the development and evaluation of improved cancer treatment methods through laboratory and translational research, consistent with the Cancer Treatment Research program's objectives to discover, develop, and clinically test novel therapeutic approaches that enhance anti-cancer immunity while reducing treatment toxicity.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $516.8k | 4/21/26 |