Project Grant R01CA308067
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $663,340 Project Grant to the University of California, Berkeley under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The award, made on August 27, 2025 with completion targeted for July 31, 2030, will fund investigations into how the local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $412,249 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the University of Illinois, Chicago to support research on novel innate immune checkpoint receptors. The award, issued May 13, 2026, with completion targeted for April 30, 2027, funds investigative work aimed at identifying and characterizing vascular cell adhesion molecule-1 (VCAM-1) receptors on phagocytic cells that mediate immune...
- Federal Grant Award Summary The University of Chicago received a $642,292 Project Grant awarded July 2, 2025, by the National Institute of Biomedical Imaging and Bioengineering under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant funds development of a chemogenetic toolbox designed to enable controlled, simultaneous expression of multiple proteins in T cells to better understand complex immune signaling networks. This...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $402,011 Project Grant to The University of Texas Southwestern Medical Center under the Cancer Biology Research program (CFDA 93.396) effective May 1, 2026, through April 30, 2031. This five-year research initiative investigates the molecular mechanisms by which the KEAP1-NRF2 redox-sensing pathway regulates CD8 T cell adaptation to chronic antigen receptor signaling in cancer and chronic infection contexts. The research...
- Federal Grant Award Summary The University of Chicago received a $185,760 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded on September 15, 2025, with completion scheduled for August 31, 2028. This award supports investigator-initiated research focused on elucidating the role of glycerol metabolism in anti-tumor immunity and cancer progression, particularly within the context of obesity-related cancer risk. The research...
- Federal Grant Award Summary The University of Chicago received a $372,628 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) awarded on September 12, 2025, with a completion date of August 31, 2028. This award supports the development and advancement of spatiomolecular profiling technologies for human cancer research. Specifically, the project focuses on developing Array-Seq, a large-format spatially resolved transcriptomics...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $733,864 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Beckman Research Institute of the City of Hope, effective June 1, 2026, through May 31, 2031. This five-year research initiative focuses on identifying and characterizing stimulatory immune checkpoints that regulate macrophage-mediated programmed cell removal (PRCR) in tumor immunosurveillance. Using high-throughput CRISPR-based screening...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $257,472 to The Trustees of Columbia University in the City of New York, Health Sciences Division, effective September 6, 2025, through March 6, 2029, under the Cancer Research Manpower program (CFDA 93.398). This award supports research to dissect the impact of genomic variants on T cell anti-tumor activity, with the objective of enhancing T cell-based immunotherapies for melanoma and leukemia...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Michigan a $646,920 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning March 11, 2026, with completion targeted for February 28, 2031. This award supports research into novel multi-targeted therapeutic strategies to address chemotherapy-resistant T-cell lymphomas (TCL) and their tumor microenvironment. The research addresses critical treatment gaps by investigating mechanisms of...
The National Cancer Institute awarded a $588,289 Project Grant to the University of Chicago under the Cancer Biology Research program (CFDA 93.396) to investigate the non-apoptotic immunomodulatory mechanisms of BCL-2 family protein-targeting therapeutics in T cells. The award, effective May 1, 2026, through April 30, 2031, supports mechanistic research characterizing how BH3-mimetic drugs alter T cell function, plasticity, and mitochondrial dynamics. The research is designed to elucidate the functional consequences of BCL-2 protein-protein interaction disruption in human T cells used for adoptive cell therapy, with the ultimate objective of broadening the clinical translatability of this drug class and identifying novel immunomodulatory mechanisms distinct from apoptosis. This fundamental research initiative addresses a critical gap in understanding how anti-apoptotic protein targeting affects discrete immune cell populations and immune system adaptation. By dissecting BCL-2 family protein regulation in T cells independent of cell death pathways, the project aims to optimize BH3-mimetic therapeutic applications and support the development of T cell-based cancer therapies. The five-year project period aligns with the Cancer Biology Research program's emphasis on investigator-initiated, mechanistic research addressing fundamental questions in cancer biology with translational potential.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $588.3k | 4/27/26 |