Project Grant R01CA304148
- Federal Project Grant Award Summary The National Cancer Institute (National Institutes of Health) awarded the University of Florida's Division of Sponsored Research $394,687 under the Cancer Treatment Research program (CFDA 93.395) effective August 18, 2025, with completion targeted for July 31, 2027. This project grant supports research focused on enhancing antitumor efficacy through intratumoral delivery of LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1) inhibitory signaling. The...
- Federal Project Grant Award Summary Weill Medical College of Cornell University received a $472,730 project grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective August 1, 2025, through July 31, 2030. This five-year project investigates the role of the tumor suppressor KEAP1 (Kelch-like ECH-associated protein 1) in antitumor immunity, with specific focus on understanding how loss-of-function KEAP1 mutations contribute to immune...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Grant Award Summary Emory University received a $646,181 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) to conduct a five-year research initiative examining the role of clonal hematopoiesis (CH) in non-small cell lung cancer (NSCLC) development and immune evasion. The award, effective April 2, 2026, through March 31, 2031, supports fundamental cancer biology research aimed at understanding how age-related mutations in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Mayo Clinic Jacksonville $498,582 under the Cancer Biology Research program (CFDA 93.396) for a five-year project grant (R01) commencing June 1, 2026 and concluding May 31, 2031. This award supports fundamental research investigating how acetylation—a post-translational modification process—modulates T cell receptor (TCR) signaling to enhance anti-tumor immune responses. The project delivers research services focused on...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $1.10M under the Cancer Treatment Research program (CFDA 93.395), effective August 13, 2025, through April 30, 2030. This research project investigates the transcriptional and epigenetic mechanisms controlling CD8+ tumor-infiltrating lymphocytes (TILs), with a focus on understanding how the transcription factor BCL11B regulates critical T...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Illinois a $412,249 Project Grant under the Cancer Biology Research program (CFDA 93.396) on May 13, 2026, for research focused on identifying novel innate immune checkpoint receptors that regulate phagocytosis in cancer and transplantation contexts. The project, scheduled for completion by April 30, 2027, will deliver research products addressing two specific aims: (1) identification and validation of...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Project Grant Summary The National Cancer Institute awarded the University of Pittsburgh a $408,829 Project Grant under the Cancer Biology Research program (CFDA 93.396) on March 13, 2026, with completion scheduled for February 29, 2028. This award funds research investigating immunosuppression mediated by regulatory CD8+ T cells in lung cancers, specifically examining how these immunosuppressive cells contribute to immune evasion and resistance to checkpoint inhibitor immunotherapy. The...
- Federal Project Grant Award Summary Baylor College of Medicine received a $411,404 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded on August 20, 2025, with a completion date of July 31, 2027. This research initiative aims to identify genes with a significant deficit of loss-of-function (LOF) mutations in lung tumors, a novel approach to cancer-related gene identification. The project utilizes statistical regression modeling and...
The University of Florida received a $487,056 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) to investigate the mechanisms by which LKB1 tumor suppressor gene inactivation drives immune evasion and therapeutic resistance in non-small cell lung cancer (NSCLC). The award, effective July 1, 2026 through June 30, 2031, supports a five-year research initiative examining how LKB1 mutations suppress CIITA (Class II transactivator) and MHC (major histocompatibility complex) Class II expression in cancer cells, impairing antigen presentation and promoting immune evasion. The research will produce mechanistic insights into cancer cell-intrinsic immune suppression pathways and preclinical evidence supporting therapeutic strategies to restore antigen presentation capability. The project delivers research outputs across two specific aims: defining the regulation and role of tumor cell-intrinsic CIITA/MHC II in LKB1-deficient lung cancer through single-cell RNA sequencing studies, syngeneic tumor models, and human NSCLC cell line analysis; and evaluating the therapeutic impact of restoring CIITA/MHC II levels on enhancing antitumor immunity and improving immunotherapy responsiveness. These investigations will establish a new mechanistic framework and identify therapeutic vulnerabilities in LKB1-mutant tumors, addressing a critical gap in understanding how specific tumor suppressor mutations drive resistance to standard therapies including immune checkpoint blockade.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $487.1k | 6/19/26 |