Project Grant R01CA304089
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $730,097 to the Sloan-Kettering Institute for Cancer Research, effective May 1, 2026 through April 30, 2031, under the Cancer Treatment Research program (CFDA 93.395). This research project addresses the suppression of anti-tumor T-cell immunity in gastric adenocarcinoma by investigating how chronic inflammation induces KLF-2 (Krüppel-like factor 2)—a quiescence-associated transcription factor—in...
- Federal Grant Award Summary The National Cancer Institute awarded a $671,252 Project Grant to Sloan-Kettering Institute For Cancer Research under the Cancer Biology Research program (CFDA 93.396) to investigate the mechanisms of anti-tumor immunity mediated by immune cell triads. The research project, effective from July 1, 2026 through June 30, 2031, will advance fundamental understanding of how CD4 T cells, CD8 T cells, and dendritic cells must spatially organize and interact within tumors...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $418,176.00 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This three-year award supports the advanced development and validation of programmable nucleic acid cytometry, a technology designed to isolate and profile rare cell populations from tumors and tissues. Building on the...
- Federal Grant Award Summary The National Cancer Institute (NCI), under its Cancer Biology Research program (CFDA 93.396), awarded a $733,864 Project Grant to the Beckman Research Institute of the City of Hope, effective June 1, 2026 through May 31, 2031. The award funds fundamental research to identify and characterize stimulatory immune checkpoints that regulate macrophage-mediated programmed cell removal (PRCR), a critical process in tumor immunosurveillance and cancer elimination. Using...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Broad Institute, Inc. a Project Grant of $245,297 effective July 1, 2026, through June 30, 2029, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The award supports research to develop chimeric molecules that generate neoantigens from proteins dysregulated in cancer and infectious disease. The project involves constructing bifunctional molecules by combining clinical-grade protein binders with...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $648,626 to the University of California, Irvine, effective April 2, 2026, through March 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This award supports research investigating the mechanisms of immunosuppression triggered by checkpoint blockade immunotherapy (CBI), specifically how programmed death receptor 1 (PD-1) blockade affects tumor microenvironments. The research seeks to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $716,521 to Sloan-Kettering Institute for Cancer Research on August 25, 2025, under the Cancer Treatment Research program (CFDA 93.395). The award supports the development and clinical evaluation of DLL3-targeted IL18-secreting chimeric antigen receptor (CAR) T cells for treating small cell lung cancer (SCLC). The research initiative addresses a critical clinical need, as SCLC currently demonstrates...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $694,015 to the Beckman Research Institute of the City of Hope under the Cancer Biology Research program (CFDA 93.396) for a five-year Project Grant beginning July 1, 2026, and concluding June 30, 2031. The award funds fundamental research focused on identifying and targeting cancer immune evasion mechanisms, specifically examining how tumor-associated macrophages (TAMs) recognize and eliminate cancer cells through a process...
- Federal Grant Award Summary The National Cancer Institute awarded The Institute For Cancer Research a $186,000 Project Grant under the Cancer Treatment Research program (CFDA 93.395) on June 23, 2025, with a completion date of May 31, 2027. The award supports pilot and feasibility studies for NN-01-195, a novel tumor-targeted Aurora-A kinase (AURKA) inhibitor developed through a drug conjugate approach. The research involves preclinical evaluation of this chimeric compound, which fuses an...
The National Cancer Institute awarded $748,410 to Scripps Research Institute under the Cancer Treatment Research program (CFDA 93.395) on June 19, 2026, to support a five-year project extending through May 31, 2031. This Project Grant funds research on targeted degradation of glycoimmune checkpoints Siglec-7 and Siglec-9 for cancer immunotherapy. The research will develop heterobifunctional degrader molecules that simultaneously target both Siglec proteins to the lysosome for degradation, with the objective of enhancing immune cell-mediated tumor destruction in solid tumors including melanoma and pancreatic cancer. The funded research encompasses three primary research objectives: construction of an unnatural sialic acid derivative library to identify improved ligands with high affinity and exclusive specificity for Siglec-7 and Siglec-9; development of degraders that specifically target and degrade both proteins; and evaluation of degradation efficacy, pharmacokinetics, and toxicity profiles. The innovation addresses a significant gap in cancer immunotherapy by developing a novel approach to disable immune checkpoints that operate orthogonally to current FDA-approved therapies (anti-PD-1 and anti-CTLA-4), with potential application as monotherapy or in combination regimens for treatment-refractory tumors.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $748.4k | 6/23/26 |