Project Grant R01CA303566
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $533,245 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective June 1, 2026, through May 30, 2031. The grant supports fundamental research to develop therapeutic strategies targeting leukemia-initiating cells (LICs) in acute myeloid leukemia (AML) through investigation of protein glutathionylation—a post-translational modification that...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded Cincinnati Children's Hospital Medical Center a $1.48M Project Grant on September 1, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393) to develop and evaluate SUMMIT (Supporting Medication Management with Individualized Treatment), a tailored medication adherence-promotion intervention designed specifically for adolescents and young adults (AYAs) with cancer. The five-year award, extending through...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $683,698 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective June 1, 2026 through May 31, 2031. The award supports research to develop and validate a novel therapeutic strategy for treating high-risk B-cell acute lymphoblastic leukemia (B-ALL), particularly in relapsed/refractory cases and those resistant to anti-CD19 therapy. The primary...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $481,500 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), awarded August 15, 2025, with a completion date of August 14, 2027. The grant funds the enhancement of DeGAUSS (Decentralized Geomarker Assessment for Multi-Site Studies), an open-source research tool that transforms geocoding and exposure assessment models into FAIR...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $731,130 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 19, 2025, with completion scheduled for June 30, 2030. The award supports a multi-site, two-stage Sequential, Multiple Assignment, Randomized Trial (SMART) evaluating the effectiveness of a stepped-care mobile health intervention called ASTHMA...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $866,250 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective September 9, 2025, with completion targeted for August 31, 2027. The award supports research to develop predictive approaches and biomarkers for mitigating drug-induced liver injury (DILI) in pediatric populations....
- Federal Project Grant Award Summary The Research Institute at Nationwide Children's Hospital received a $406,258 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) for the period May 1, 2026 through April 30, 2028. The award supports MEDMEMOS, a novel adherence promotion intervention designed to improve medication management in pediatric allogeneic hematopoietic stem cell transplantation (PAHCT) patients. The primary...
- Grant Award Summary Cincinnati Children's Hospital Medical Center received a $530,106 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded September 11, 2025, with completion by August 31, 2030. The research project targets polyamine metabolism in leukemia stem cells (LSCs) to develop therapeutic interventions for acute myeloid leukemia (AML). The project delivers fundamental research investigating the mechanistic role of...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $727,575 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with completion targeted for May 31, 2030. The project will investigate the cellular mechanisms and clinical impact of the genetic variant rs7512462 within the SLC26A9 gene on individual patient responses to cystic fibrosis (CF)...
- Federal Grant Award Summary The National Cancer Institute awarded a $639,295 Project Grant to the Research Institute at Nationwide Children's Hospital on May 8, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393). This award supports a five-year research initiative extending through April 30, 2031, focused on elucidating the molecular mechanisms governing fusion oncoproteins derived from FET (Fused in Ewing sarcoma, Ewsr1, Taf15) family members fused to ETS transcription...
Cincinnati Children's Hospital Medical Center received a $694,182 Project Grant award dated June 1, 2026, from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a prospective longitudinal cohort study examining biomarker levels and health effects associated with tobacco product exposure in young children. The five-year research initiative (completion date May 31, 2031) will enroll 300 children ages 1-10 years in three equal cohort groups: those exposed to electronic cigarettes (ECs), those exposed to combustible cigarettes (CCs), and unexposed controls living with non-tobacco users. The research deliverables include collection and analysis of tobacco exposure and oxidative stress biomarkers, assessment of epigenetic changes including DNA methylation and epigenetic age acceleration, and evaluation of respiratory health outcomes across the study period to determine whether EC exposure presents a lower health risk profile compared to CC exposure in children. The project addresses a critical research gap by providing the first longitudinal comparison of EC and CC exposure patterns and health effects in children, generating evidence to support public health guidance regarding tobacco product safety in pediatric populations. Research activities will be performed at Cincinnati Children's Hospital Medical Center's location in Cincinnati, Ohio.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $694.2k | 6/1/26 |