Project Grant R01CA301398
- Federal Project Grant Award Summary The University of California, Davis received a $149,394 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective August 1, 2025 through July 31, 2030. This award supports research in targeted radiotheranostics—the development and clinical translation of diagnostic and therapeutic radiopharmaceuticals that enable integrated imaging and treatment of cancer. The research encompasses the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded University of California, Davis a $551,328 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective April 1, 2026, with a completion date of March 31, 2031. This five-year research initiative focuses on dissecting the role of Carnitine Palmitoyltransferase 1C (CPT1C) in advanced prostate cancer, specifically neuroendocrine prostate cancer (NEPC), an aggressive subtype that emerges from...
- Federal Grant Award Summary The National Cancer Institute (NCI), under its Cancer Biology Research program (CFDA 93.396), awarded a $661,721 Project Grant to the University of California, San Diego, with an award date of April 1, 2026, and a completion date of March 31, 2031. This five-year research initiative focuses on systematic functional mapping and interrogation of oncogenic intrinsically disordered regions (IDRs) in cancer driver proteins. The project will utilize novel high-throughput...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $615,399 Project Grant to the University of California, Davis under the Cancer Treatment Research program (CFDA 93.395) for the period August 1, 2025, through July 31, 2030. The award supports the development of a transformable nanoparticle (TNP) platform designed to deliver therapeutic peptides and proteins directly to tumor microenvironments on-demand. The TNP technology transforms from nanoparticles to nanofibrils...
- Federal Grant Award Summary The National Cancer Institute awarded a $403,686 Project Grant to the University of California, Irvine under the Cancer Treatment Research program (CFDA 93.395) effective March 19, 2026, with a completion date of February 28, 2027. This research initiative will develop and validate a genetic screening approach to identify synergistic drug-diet interactions that enhance cancer therapy efficacy. The principal deliverables include the establishment of an unbiased,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $418,176 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) to advance programmable nucleic acid cytometry technology for isolating and analyzing rare cell populations from tumors and tissues. The three-year project, initiated September 1, 2025 and concluding August 31, 2028, focuses on continued development and validation of Programmable Enrichment via RNA...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded University of California, San Diego a $410,115 project grant under the Cancer Biology Research program (CFDA 93.396) beginning August 1, 2025, with completion scheduled for July 31, 2027. This research initiative develops improved preclinical models for pancreatic ductal adenocarcinoma (PDAC) by incorporating three-dimensional high-density type I collagen into tumor modeling systems. The project addresses a...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $421,685 Project Grant to The Regents of the University of California, San Francisco under the Cancer Biology Research program (CFDA 93.396) for research activities spanning August 8, 2025 through July 31, 2027. This award funds a discovery-focused research initiative investigating functional immune niches within the tumor microenvironment (TME) that support effective cancer immunotherapy responses. The primary deliverable...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded University of California, San Diego a $534,083 Project Grant effective June 3, 2025, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on glucocorticoid signaling mechanisms induced by breast cancer cell-derived extracellular vesicles. The research project, scheduled for completion by May 31, 2030, will investigate how extracellular vesicles produced by breast cancer cells trigger...
- Federal Grant Award Summary The National Cancer Institute awarded a $663,340 Project Grant to the University of California, Berkeley on August 27, 2025, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on regulatory T cell-mediated suppression of tumor elimination. The research will elucidate mechanisms by which local ablation of intra-tumoral regulatory T cells (IT-Tregs) mobilizes natural killer (NK) cells and CD4 T cells to control tumors that have...
The National Cancer Institute (NCI) awarded $648,177 to the University of California, Davis under the Cancer Biology Research program (CFDA 93.396) on April 1, 2026, for a project extending through February 28, 2031. The award supports fundamental research into glycolytic metabolic heterogeneity at the single-cell level, addressing a critical gap in understanding how glucose disposal and lactate production vary across cellular populations. The research team will develop and validate mathematical models of glycolytic rate distributions using multiplexed live-cell measurements of key metabolic markers, including fructose 1,6-bisphosphate (FBP), NADH/NAD+ ratios, and kinase activities. This work has direct relevance to understanding metabolic dysfunction in diabetes, cancer, and immune function. The project will deliver quantitative modeling frameworks and experimental validation demonstrating how dual measurements of FBP and NADH/NAD+ can constrain single-cell glucose disposal and lactate production rate distributions. Additionally, the research will investigate how the AKT/AMPK/MTOR signaling network links glycolytic rates to protein synthesis, creating time-dependent metabolic variation and microenvironments affecting cellular differentiation and death. The anticipated outcomes will advance fundamental knowledge of cancer cell metabolism and potentially identify new therapeutic vulnerabilities through characterization of metabolic heterogeneity in epithelial, muscle, and liver cell models.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $648.2k | 3/24/26 |