Project Grant R01CA300695
- Federal Grant Award Summary The University of Washington received a $369,468 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for research on efficient, cost-effective, and ultrasensitive sequencing of somatic mutations and methylation. The award, effective September 1, 2025, through August 31, 2028, supports the development of next-generation sequencing (NGS) technologies capable of detecting and quantitating genetic and...
- Federal Grant Award Summary The University of Washington received a $686,271 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded May 1, 2026, with completion expected April 30, 2031. This five-year award supports development of proteomics-driven analysis and robotics-enabled drug testing methodologies for microdissected tumors and their microenvironment. The research leverages advanced tissue manipulation...
- Federal Grant Award Summary The University of Wisconsin-Madison received a $2.58 million Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded August 11, 2025, and extending through July 31, 2030. This multi-institutional research program investigates the molecular drivers and therapeutic susceptibilities in lineage state transitions of metastatic castrate-resistant prostate cancer (MCRPC). The project addresses critical...
- Federal Project Grant Award Summary The National Cancer Institute awarded the University of Washington $278,494 on August 1, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support a K08 Mentored Research Scientist Development Award. This five-year project, concluding July 31, 2030, funds the career development and research training of an Assistant Professor of Medicine and primary care physician to become an independent clinician investigator specializing in cancer screening...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $603,981 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded August 18, 2025, with completion targeted for July 31, 2030. This research initiative develops and validates integrated clinical-grade artificial intelligence (AI) biomarkers combining genomic and digital pathology analysis to improve risk stratification and treatment...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Regents of the University of California, San Francisco a Project Grant of $679,290 under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for the period April 1, 2026 through March 31, 2031. The project focuses on translating novel hyperpolarized (HP) carbon-13 dual-agent magnetic resonance imaging (MRI) techniques to improve prostate cancer detection and biopsy guidance. The research aims to develop and...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $512,728 Project Grant effective August 1, 2025, through May 31, 2030, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). The award supports development and clinical evaluation of PROBOT, a novel ultrasound probe and robotic system designed to improve image-guided interventions for prostate cancer diagnosis and treatment. The project encompasses a Phase 1...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a Project Grant of $531,825 under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, with completion targeted for July 31, 2030. This research initiative focuses on understanding the molecular mechanisms of castration sensitivity in prostate epithelium, with the ultimate goal of improving therapeutic responses to androgen-deprivation therapy...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Fred Hutchinson Cancer Center a Project Grant totaling $139,184 under the Cancer Research Manpower program (CFDA 93.398) for the period of July 1, 2025, through June 30, 2027. This award funds research investigating the role of RNA components of the translation apparatus in prostate cancer plasticity and therapy response. The project focuses on elucidating how prostate cancer leverages transfer RNA (tRNA) and 5'...
The University of Washington received a $688,959 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective April 1, 2026 through March 31, 2031. This award funds the Stratifying Underlying Risk in the Prostate Cancer Active Surveillance Study (SURPASS), which will develop and validate predictive biomarker tools for identifying favorable-risk prostate cancer patients who progress to aggressive disease. The research leverages the Canary Prostate Active Surveillance Study (PASS) cohort—a prospectively accrued, multi-institutional North American cohort of 2,300 participants with extensive clinical, imaging, and longitudinal biospecimen data—to interrogate novel radiomic, pathomic, and liquid biomarkers for early cancer progression identification. The primary deliverable is a validated predictive tool that will accurately identify patients initially diagnosed with favorable-risk prostate cancer who will progress to aggressive phenotypes (Grade Group >3 cancer, recurrence after treatment, or metastasis) better than routine clinical assessments. This tool addresses a critical clinical need, as approximately 20% of cancers appearing low-risk at diagnosis progress to aggressive forms, and currently no biomarker tests have been validated for clinical use in the large active surveillance population. Early identification of these aggressive cancers will enable timely treatment intervention when curative outcomes are most likely, reducing unnecessary treatment in stable patients while improving outcomes for those requiring intervention.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.0k | 3/24/26 |