Project Grant R01CA299650
- Federal Grant Award Summary The University of Washington received a $369,468 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) for research on efficient, cost-effective, and ultrasensitive sequencing of somatic mutations and methylation. The award, effective September 1, 2025, through August 31, 2028, supports the development of next-generation sequencing (NGS) technologies capable of detecting and quantitating genetic and...
- Federal Grant Award Summary The University of Washington received a $688,959 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective April 1, 2026 through March 31, 2031. This award funds the Stratifying Underlying Risk in the Prostate Cancer Active Surveillance Study (SURPASS), which will develop and validate predictive biomarker tools for identifying favorable-risk prostate cancer patients who progress to aggressive...
- Federal Grant Award Summary The University of Wisconsin-Madison received a $2.58 million Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded August 11, 2025, and extending through July 31, 2030. This multi-institutional research program investigates the molecular drivers and therapeutic susceptibilities in lineage state transitions of metastatic castrate-resistant prostate cancer (MCRPC). The project addresses critical...
- Federal Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded a $427,625 Project Grant to the University of Washington, effective September 1, 2025, through August 31, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). This award supports the development of capillaric microfluidics technology for integrated, self-powered, and self-regulated sample preparation in miniaturized mass spectrometry (MS) systems. The research addresses a...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $584,510 to the University of Colorado-Denver on September 12, 2025, under the Cancer Biology Research program (CFDA 93.396) to support the development and implementation of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. Through the Human Immune Monitoring Shared Resource (HIMSR) at the University of Colorado Cancer Center, this funding supports a...
- Federal Grant Award Summary The University of Washington received a $2.1 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded May 1, 2026, with completion targeted for April 30, 2030. The award supports the development of ultrahigh multiplexing (>1000-plex) fluorescent probes and associated methods for spatial transcriptomics applications. The primary deliverable is a set of...
- Federal Grant Award Summary The University of Chicago received a $372,628 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective September 12, 2025, through August 31, 2028. This award supports the development and advancement of spatiomolecular profiling technologies for cancer research, specifically building upon the institution's Array-Seq large-format spatially resolved transcriptomics (ST) platform. The project...
- Federal Grant Award Summary The National Cancer Institute awarded $138,846 to the University Health Network under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a two-year Project Grant commencing August 1, 2025 and concluding July 31, 2027. The award supports the development of laboratory-generated "wild-like" mouse models designed to enhance the translational relevance of preclinical cancer and immunotherapy research. The primary deliverable involves adapting...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Johns Hopkins University a $512,728 Project Grant effective August 1, 2025, through May 31, 2030, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). The award supports development and clinical evaluation of PROBOT, a novel ultrasound probe and robotic system designed to improve image-guided interventions for prostate cancer diagnosis and treatment. The project encompasses a Phase 1...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a Project Grant totaling $399,829 under the Cancer Treatment Research program (CFDA 93.395) for the period April 1, 2026 through March 31, 2028. The award funds research focused on rational design of next-generation engineered T cells to enhance cancer immunotherapy by addressing the critical challenge of limited T cell persistence. The project employs structure-informed protein design to optimize 4-1BB...
The University of Washington received a $686,271 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded May 1, 2026, with completion expected April 30, 2031. This five-year award supports development of proteomics-driven analysis and robotics-enabled drug testing methodologies for microdissected tumors and their microenvironment. The research leverages advanced tissue manipulation technologies to create miniaturized disease models and personalized drug testing workflows that preserve critical features of the native tumor microenvironment, including vascular structures and immune cells, while reducing reliance on traditional tissue culture and animal models. The project delivers a high-throughput microdissected tumor tissue (MDT) approach utilizing custom robotic platforms to rapidly dissect thousands of regularly-sized tissue cuboids (approximately 400 micrometers) from individual biopsies. By maintaining intact tumor microenvironment features during testing—including immune cells and vascular structures—this methodology enables more clinically-relevant cancer disease modeling and drug evaluation for combination therapies and immunotherapies. The integrated proteomics analysis and robotics-enabled testing platform advances personalized oncology approaches while maximizing the utility of scarce human biopsies and minimizing unnecessary animal testing.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.3k | 4/15/26 |