Project Grant R01CA300362
- Federal Project Grant Award Summary The University of Utah received a $154,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective August 1, 2025, through July 31, 2027. This technology-oriented project will develop and validate a novel genetic mouse model system for pancreatic ductal adenocarcinoma (PDAC) research. The primary deliverable is the creation and functional validation of a "FLP-OUT" mouse model using a...
- Federal Grant Award Summary The University of Utah's Office of Sponsored Projects received a $183,600 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective September 1, 2025, through August 31, 2028. This award supports research investigating the combination of JAK (Janus kinase) inhibitors with immune checkpoint inhibitors to overcome resistance to checkpoint blockade immunotherapy in cancer patients, particularly those with relapsed...
- Federal Grant Award Summary The National Cancer Institute awarded a $669,949 Project Grant (CFDA 93.396, Cancer Biology Research program) to the University of Utah, effective August 15, 2025, through July 31, 2030, to elucidate the functional role and therapeutic potential of G Protein-Coupled Receptor Kinase 2 (GRK2) in primary and therapy-resistant basal cell carcinoma (BCC). The research addresses a critical therapeutic gap in BCC treatment, where existing Smoothened (SMO) inhibitors lose...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Grant Award Summary The National Cancer Institute awarded The University of Texas MD Anderson Cancer Center a $420,400 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2027. This award supports exploratory studies investigating cellular resistance mechanisms to second-generation MTA-cooperative PRMT5 inhibitors (MTA:PRMT5I) in MTAP-loss tumors. The research addresses a critical clinical challenge whereby 40-60% of patients...
- Federal Grant Award Summary The National Cancer Institute (NCI), under its Cancer Biology Research program (CFDA 93.396), awarded a $661,721 Project Grant to the University of California, San Diego, with an award date of April 1, 2026, and a completion date of March 31, 2031. This five-year research initiative focuses on systematic functional mapping and interrogation of oncogenic intrinsically disordered regions (IDRs) in cancer driver proteins. The project will utilize novel high-throughput...
- Federal Grant Award Summary The National Cancer Institute awarded $2.82 million to the Regents of the University of Michigan under the Cancer Treatment Research program (CFDA 93.395) on August 6, 2025, with completion targeted for July 31, 2029. This Project Grant supports the development of new methods to measure metabolic pathway activity in glioblastomas (GBMs), deadly brain cancers that rewire their metabolism to enable growth, invasion, and treatment resistance. The research deliverables...
- Federal Project Grant Summary Colorado State University received a $629,341 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on September 12, 2025, with an ultimate completion date of August 31, 2030. The research project focuses on developing improved cancer treatment methods through investigation of Focal Adhesion Kinase (FAK) inhibition as a dual-targeting strategy for osteosarcoma, the most common primary malignant...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $135,993 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) effective December 1, 2025, with completion anticipated by May 31, 2027. The award funds investigative research examining the role of the Abelson (ABL) kinase-regulated hypoxia inducible factor-1 alpha (HIF-1A) and transcriptional co-activator with PDZ-binding motif (TAZ) signaling...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Miami's Office of Research Administration within the School of Medicine a Project Grant totaling $109,076.00 under the Cancer Research Manpower program (CFDA 93.398) on December 17, 2025. The award supports biomedical research training and career development initiatives focused on cancer research through September 1, 2029. This project grant funds the institution's capacity to provide integrated...
The University of Utah received a $634,900 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026, through March 31, 2031. This award funds research investigating the combined effects of Focal Adhesion Kinase (FAK) inhibition with Mitogen-Activated Protein Kinase (MAPK) blockade as a therapeutic strategy for brain metastases arising from cutaneous melanoma. The research deliverables include preclinical development and evaluation of this novel combination treatment approach using an established mouse model of melanoma that develops brain and lung metastases similar to human disease, along with mechanistic studies designed to identify how FAK inhibition can be effectively combined with standard-of-care targeted therapies such as BRAF and MEK inhibitors or immunotherapy. The project addresses a critical clinical need, as melanoma patients with brain metastases currently experience dismal prognosis with median overall survival of approximately one year despite existing treatments. The research team will utilize proteomics and pharmacological approaches to delineate mechanisms by which FAK promotes metastatic disease and evaluate the therapeutic potential of FAK as an alternative target to AKT inhibition, which has demonstrated limited efficacy or significant toxicity in prior clinical trials. This fundamental and applied laboratory research supports the Cancer Treatment Research program's objective to develop improved methods of cancer treatment through discovery, development, and evaluation of novel therapeutic modalities.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 3/31/26 | ||
| Not listed | $634.9k | 3/27/26 |