Project Grant R03CA305593
- This federal Project Grant award of $472,921.00, awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research), supports research to investigate the role of the CR1 signaling pathway in regulating cellular plasticity and breast cancer progression. The University of Utah is conducting this research, which aims to understand the molecular mechanisms by which CR1 mediates stress-adaptive cell state changes in breast cancer cells and their surrounding microenvironment. The project...
- This Project Grant award of $138,846 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) supports a research project to develop "wild-like" laboratory mouse models that better mimic the adult human immune system. The goal is to produce mice with a more mature immune profile, in contrast to the immature immune system typically seen in standard laboratory mice, to enable more accurate translation of cancer and immunotherapy research findings...
- This $410,115 Project Grant was awarded by the National Cancer Institute, under the Cancer Biology Research program (CFDA 93.396), to the University of California, San Diego (UC San Diego) to support research aimed at improving preclinical models of metastatic pancreatic cancer. The research project seeks to understand how the collagen-rich tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) drives metastasis and treatment resistance, and to develop a synthetic 3D high density...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $153,278 to develop a genetically engineered mouse model (GEMM) for NUT carcinoma, a rare and aggressive form of cancer. The project, conducted by the collaborative research partnership of Henry Ford Health and Michigan State University Health Sciences, aims to create a mouse model that faithfully recapitulates the key features of NUT carcinoma to enable critical insights...
- This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $194,013 to Sanford Research, a non-profit biomedical research organization, to develop the first genetically engineered mouse models that accurately replicate key features of human high-risk rhabdomyosarcoma. The goal is to use these advanced preclinical models to explore the role of the NOTCH1 signaling pathway as both a driver and potential therapeutic target for this aggressive form...
- The University of Illinois was awarded a $160,330 Project Grant from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) with a performance period of December 1, 2024 to November 30, 2026. The project seeks to develop novel human-relevant lung adenocarcinoma models by genome editing primary human lung stem and progenitor cells, and culturing them as tumor organoids or orthotopically xenografting them into mice. The goal is to create models that more accurately reflect...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $162,486 to the University of Miami to support research into a novel immunotherapy approach for pancreatic cancer using microRNA-29a. The goal is to determine how microRNA-29a can regulate T cell exhaustion and restore anti-tumor immunity in pancreatic ductal adenocarcinoma (PDAC), which has a very low 5-year survival rate of 12%. The research will utilize the KPC mouse model of PDAC...
- This $1,271,498 Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) Division, aims to demonstrate the utility of a transgenic porcine (pig) model of pancreatic cancer for testing novel neoadjuvant therapies and evaluating endoscopic medical devices for imaging and treatment. The key objectives are: 1) to show that the porcine model can...
- This Project Grant award of $754,511 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at the Jackson Laboratory to discover host genetic factors that influence response to immune checkpoint inhibitor (ICI) cancer treatments. The project aims to: Expand and refine a mouse experimental platform to map quantitative trait loci (QTLs) associated with ICI response, focusing on defining the genetic mechanisms behind epistatic interactions. Challenge top...
- The University of Pittsburgh received a $585,931 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) on February 3, 2025. The grant will fund a comprehensive research framework to determine the molecular credentials and selection of cancer models, such as cell lines, patient-derived xenografts (PDX), and patient-derived organoids (PDO), to guide translational and clinical applications in breast cancer. The key objectives are: (1) identifying and...
This federal Project Grant award of $154,000.00 was provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) to the University of Utah. The project, titled "One Cell, One Cancer: A Novel Genetic Approach to Mouse Models of Human Cancer Initiation," aims to develop a novel dual-recombinase system, termed "Flp-out," to induce oncogenic mutations in single cells for improved modeling of pancreatic ductal adenocarcinoma (PDAC) initiation in mice. The award period runs from August 1, 2025, to July 31, 2027, and the project will focus on creating the Flp-out mouse model using CRISPR-Cas9 technology and validating its utility for PDAC research in Aim 1 and Aim 2, respectively. This award supports the University of Utah's expertise in cancer research and genetic engineering approaches to develop advanced mouse models for studying the initiation and progression of one of the deadliest human cancers.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $154.0k | 7/30/25 |