Project Grant R01CA300355
- Federal Grant Award Summary The University of Southern California received a $712,735 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) effective June 1, 2025, with a completion date of April 30, 2030. This award supports a Phase II randomized clinical trial investigating the synergistic therapeutic potential of SEPHB4-HSA, an ephrinB2 inhibitor, combined with pembrolizumab (PD-1 antibody) in muscle invasive bladder cancer (MIBC) patients....
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $156,426 to the University of Pittsburgh under the Cancer Research Manpower program (CFDA 93.398) to support an integrated in silico and in vivo genetic screening research project. The award, initiated December 1, 2025, with completion targeted for April 16, 2029, funds the development of subtype-specific precision therapeutic approaches for hepatocellular carcinoma (HCC). The research employs a hybrid methodology...
- Federal Project Grant Award Summary The National Cancer Institute awarded $724,840 to The Regents of the University of California, San Francisco on August 21, 2025, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a five-year research initiative examining the relationship between persistent poverty and colorectal cancer risk. The project, extending through July 31, 2030, will deliver research services analyzing multi-level drivers of colorectal cancer risk across...
- Federal Project Grant Award Summary The University of Southern California received a $616,715 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113), with an award date of August 1, 2025 and completion date of May 31, 2030. This award funds research investigating nuclear actin filaments and phase separation as drivers of heterochromatin repair mechanisms. The research addresses how cells repair double-strand...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a Project Grant of $133,598.00 under the Cancer Research Manpower program (CFDA 93.398) on June 23, 2025, with completion anticipated by May 31, 2027. This award supports research aimed at developing improved chemoprevention strategies for Familial Adenomatous Polyposis (FAP), a hereditary condition characterized by polyp formation and elevated cancer risk. The principal...
- Federal Project Grant Award Summary The University of Pennsylvania received a $667,041 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026, through February 28, 2031. This five-year project focuses on validation and credentialing of patient-derived xenograft (PDX) models of hepatocellular carcinoma (HCC) using patient-level data. The research addresses the significant clinical challenge that...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $700,838 to the University of California, San Francisco under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for a five-year Project Grant spanning April 1, 2026 through March 31, 2031. The award supports development and optimization of advanced magnetic resonance (MR) imaging and radiation therapy planning technologies to improve treatment outcomes for patients with primary and secondary liver tumors....
- Federal Grant Award Summary The University of Texas Southwestern Medical Center received a $2.88M Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), effective August 5, 2025, through July 31, 2029. This award supports the development of non-invasive, etiology-adjusted precision biomarkers for hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) risk prediction. The research builds upon previously validated...
- Federal Project Grant Summary The University of Southern California received a $426,828 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded August 15, 2025, with a completion date of July 31, 2027. This research initiative focuses on developing DNA methylation (DNAM) markers for early detection and monitoring tumor burden in bladder cancer patients. The project addresses a critical clinical need by leveraging...
- Federal Grant Award Summary Yale University received a $431,377 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective August 20, 2025, with completion targeted for July 31, 2027. This research project investigates the etiology of glioma in young children (ages 0-5 years) with a focus on prenatal exposure to per- and polyfluoroalkyl substances (PFAS) while accounting for genetic susceptibility factors. The...
The University of Southern California received a $681,676 Project Grant award from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective April 1, 2026, through March 31, 2031. The grant supports a translational research study investigating Per- and Polyfluoroalkyl Substances (PFAS) as novel risk factors for hepatocellular carcinoma (HCC) and metabolic dysfunction-associated steatotic liver disease (MASLD). The research integrates population-based epidemiological analysis of the Multiethnic Cohort Study—leveraging comprehensive data spanning over two decades and pre-diagnostic plasma samples—with in vitro experimental work utilizing three-dimensional human liver spheroids, two-dimensional HepG2 cell cultures, and omics techniques to elucidate biological pathways linking PFAS exposure to liver disease and cancer development. The project deliverables include epidemiological analyses evaluating associations between individual and mixed PFAS exposures and HCC risk, mechanistic investigations of PFAS-induced liver steatosis and carcinogenesis through cellular and molecular studies, and development of high-dimensional machine learning risk profiles for HCC incorporating PFAS plasma concentrations, multi-omics data, and genetic factors. These outputs are designed to provide evidence-based insights into personalized prevention strategies and to address a significant gap in understanding environmental chemical contributions to the rising incidence of MASLD-related liver cancer, which is projected to become the leading cause of liver cancer as viral hepatitis-related HCC declines.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $681.7k | 3/6/26 |