Project Grant R01CA299902
- Federal Grant Award Summary Purdue University received a $457,503 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on August 28, 2025, with completion expected by July 31, 2030. This award funds fundamental cancer biology research investigating the posttranslational regulation of macropinocytosis in pancreatic ductal adenocarcinoma (PDAC). The research examines how protein phosphatase 2A (PP2A), specifically the B56A subunit,...
- Federal Grant Award Summary The National Cancer Institute awarded a $661,721 Project Grant to the University of California, San Diego, under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2031. The award supports fundamental research focused on systematic functional mapping and interrogation of intrinsically disordered regions (IDRs) in oncogenic proteins. The research employs high-throughput functional screening technologies and computational...
- Federal Grant Award Summary The National Cancer Institute awarded a $506,309 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Indiana University Indianapolis, effective May 7, 2025, through April 30, 2030. The grant funds fundamental research investigating the regulation of ovarian cancer (OC) metastasis through microenvironment-induced chromatin accessibility and C-Jun activation. The research addresses a critical clinical gap by developing mechanistic understanding of...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $491,315 to the University of Colorado-Denver under the Cancer Biology Research program (CFDA 93.396) on September 12, 2025, for a project period extending through August 31, 2029. The award supports the Functional Genomics Shared Resource (FGSR) at the University of Colorado Cancer Center in advancing functional genomics and cell engineering technologies for cancer research. Under the direction of Dr. Molishree Joshi,...
- Federal Project Grant Award Summary The National Cancer Institute awarded Indiana University Indianapolis a $423,084 Project Grant under the Cancer Biology Research program (CFDA 93.396) to investigate the musculoskeletal wasting syndrome associated with metastatic colorectal cancer. The research project, initiated May 5, 2025 and extending through April 30, 2030, focuses on identifying the biological mechanisms by which cancer cachexia—a multi-organ wasting condition responsible for over 30% of...
- Project Summary Purdue University received a $2.9 million Project Grant from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) awarded August 1, 2025, through July 31, 2029. The project focuses on developing a novel therapeutic approach to suppress platelet-derived growth factor receptor B (PDGFR-B) gene expression by targeting a unique vacancy G-quadruplex (VG4) structure in the PDGFR-B promoter region. The research addresses the clinical limitation that existing...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a $418,176 Project Grant under the Cancer Biology Research program (CFDA 93.396) for the period September 1, 2025, through August 31, 2028. This award supports the continued advanced development and validation of programmable nucleic acid cytometry technology, specifically building upon the Institute's prior work with Programmable Enrichment via RNA Fluorescence In Situ Hybridization...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a $657,776 Project Grant under the Cancer Treatment Research program (CFDA 93.395) beginning August 1, 2025, and extending through May 31, 2030. This award supports the development of highly tumor-selective pan RAS inactivators to address oncogenic RAS-driven cancers, which account for approximately 46% of all human malignancies. The project addresses a significant clinical challenge: while...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $237,023 to Harvard Medical School (operating through President and Fellows of Harvard College) on March 13, 2026, under the Cancer Biology Research program (CFDA 93.396). This three-year award, with completion scheduled for February 28, 2029, supports the development and refinement of high-throughput technological tools to track the dynamics and fate of alternatively polyadenylated (APA) transcripts...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $156,426 to the University of Pittsburgh under the Cancer Research Manpower program (CFDA 93.398) to support an integrated in silico and in vivo genetic screening research project. The award, initiated December 1, 2025, with completion targeted for April 16, 2029, funds the development of subtype-specific precision therapeutic approaches for hepatocellular carcinoma (HCC). The research employs a hybrid methodology...
Purdue University received a $437,654 Project Grant from the National Cancer Institute (Cancer Biology Research program, CFDA 93.396) awarded on March 19, 2026, with a completion date of February 28, 2031. The research project, "Dissecting the Role of Tumor Suppressing MicroRNAs in Angiosarcoma," addresses the identification and functional characterization of microRNAs (miRNAs) that suppress tumorigenesis in angiosarcoma, an aggressive endothelial cell-derived soft tissue sarcoma with limited therapeutic options. The project employs CRISPR-Cas9 loss-of-function screening methodologies to identify critical tumor-suppressing miRNAs and investigates the molecular mechanisms by which miRNA loss contributes to malignant transformation in endothelial cells. The research deliverables include systematic functional analysis of novel miRNA candidates identified through preliminary screening studies, with the goal of generating fundamental cancer biology knowledge that will inform the development of novel therapeutic interventions for angiosarcoma treatment. By elucidating the role of specific miRNAs in tumorigenesis and understanding how their loss drives endothelial cell transformation, this project contributes to the Cancer Biology Research program's objective of providing fundamental information on cancer mechanisms to support improved prevention, detection, diagnosis, and treatment methodologies for neoplastic diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.7k | 3/19/26 |