Project Grant R01CA299189
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $494,160 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) beginning September 11, 2025, with a completion date of August 31, 2030. The award supports fundamental research aimed at understanding the role of Fragile X Mental Retardation Autosomal Related Protein-1 (FXR1) in ovarian cancer progression, specifically examining how FXR1 messenger RNA encapsulated within...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $234,000 Project Grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420) for the period August 1, 2025 through July 31, 2027. The project, titled "Whole-Brain Radiopathmic Mapping of Glioblastoma Infiltration," supports advanced biomedical research aimed at developing innovative diagnostic and analytical approaches to characterize glioblastoma tumor...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $156,000 Project Grant award dated June 18, 2025, from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a national cohort study examining breast cancer diagnostics, treatment, and outcomes in individuals using hormone therapy (HT). The project, which will be completed by May 31, 2027, will create a multi-institutional retrospective cohort of breast...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $552,318 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 5, 2025, through May 31, 2030. The award funds research to identify and validate carbonic anhydrase XII (CA12) as a cardioprotective target for mitigating anthracycline-induced cardiotoxicity (AIC)—a significant health concern affecting cancer...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $324,000 Project Grant award dated August 7, 2025, from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) to establish the Student-Centered Pathway to Advance Research and Cancer Careers (SPARCC). The award supports a comprehensive 12-week educational and research training program designed to recruit and mentor undergraduate students from Milwaukee-area institutions in biomedical,...
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $630,171 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective August 12, 2025 through July 31, 2030. This award supports the development of a first-in-class radiopharmaceutical therapy (RPT) targeting triple-negative breast cancer (TNBC), an aggressive cancer subtype with a five-year survival rate of 12% for metastatic cases. The research...
- Federal Grant Award Summary Baylor College of Medicine received a $412,685 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on April 10, 2025, with a completion date of March 31, 2027. This award supports fundamental research investigating the molecular mechanisms through which MYCN (a frequently amplified oncogene) creates an immunologically suppressive tumor microenvironment in high-risk neuroblastoma patients. The research will...
- Federal Grant Award Summary The University of Michigan received a $2.82 million Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded August 6, 2025, with a completion date of July 31, 2029. The project focuses on developing new methodologies to measure and interrupt metabolic fluxes in glioblastomas (GBMs), highly aggressive brain cancers that currently lack effective treatment strategies despite standard resection, radiation, and...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $156,000 Project Grant award from the National Institutes of Health Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective August 1, 2025, through July 31, 2027. This award supports the development of a biomarker panel to identify organ-specific radiation exposure through microRNA (miRNA) analysis in blood samples. The research specifically aims to discriminate between upper-body...
- Federal Project Grant Award Summary Seattle Children's Research Institute received a $470,759 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), awarded September 1, 2025, with completion targeted for August 31, 2027. This award supports research and development of PA-Regulator controlled GPC3-CAR T cells for treating hepatocellular carcinoma. The project addresses a critical therapeutic barrier: CAR T cell exhaustion in solid...
The Medical College of Wisconsin, Inc. received a $632,314 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with a completion date of March 31, 2031. This award supports research and development of gallium maltolate (GAM), an iron-mimetic metallocompound, as a novel therapeutic treatment for difficult-to-treat pediatric central nervous system (CNS) tumors, specifically pediatric high-grade gliomas (PHGGs) and atypical teratoid rhabdoid tumors (ATRTs). The research builds upon preliminary in vitro and in vivo studies demonstrating that GAM inhibits cancer cell growth and extends overall survival in orthotopic rat models by targeting dysregulated iron homeostasis pathways unique to CNS cancers. The project aims to advance GAM toward clinical application through continued preclinical and translational research, addressing a critical clinical need for less toxic, more efficacious treatment options for aggressive pediatric brain tumors that currently rely on burdensome multi-modal treatment protocols with significant quality-of-life impacts. The research will be conducted at the awardee's facility in Wauwatosa, Wisconsin, and represents the National Cancer Institute's investment in developing improved cancer treatment modalities through fundamental and applied laboratory research within the Cancer Treatment Research program.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $632.3k | 3/9/26 |