Project Grant R01CA297178
- Federal Grant Award Summary The National Cancer Institute awarded a $411,206 Project Grant to the University of California, San Diego under the Cancer Treatment Research program (CFDA 93.395) on May 14, 2026, with a completion date of April 30, 2028. This award supports the development of small molecule inhibitors targeting the proton-sensing receptor GPR68 for pancreatic ductal adenocarcinoma (PDAC) therapy. The research addresses a critical clinical need, as PDAC accounts for approximately 90%...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $119,858 to the Regents of the University of Minnesota under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, for a project extending through July 31, 2030. This project grant supports fundamental research aimed at elucidating and overcoming T cell dysfunction in pancreatic ductal adenocarcinoma (PDA), a disease notoriously resistant to immunotherapy. The research program comprises three...
- Federal Grant Award Summary Purdue University received a $457,503 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) on August 28, 2025, with completion targeted for July 31, 2030. The research project focuses on elucidating the posttranslational regulation of macropinocytosis in pancreatic ductal adenocarcinoma (PDAC), specifically investigating the role of protein phosphatase 2A (PP2A) subunit B56A in regulating nutrient-scavenging...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $120,403 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded on June 1, 2026, with a completion date of May 31, 2027. This award supports research development focused on pancreatic ductal adenocarcinoma (PDAC) detection and patient risk stratification. The project delivers ultrasensitive maximum depth sequencing (MDS) services...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $683,970 Project Grant to Columbia University's Health Sciences Division effective April 1, 2026 through March 31, 2031, under the Cancer Treatment Research program (CFDA 93.395). This research project focuses on developing and evaluating therapeutic approaches to treat pancreatic ductal adenocarcinoma (PDAC) through stromal modification and immune modulation. The research investigates the role of αvβ5 integrin in PDAC...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded Columbia University's Health Sciences Division a Project Grant of $100,228 effective December 1, 2026, with a completion date of May 31, 2028. The award supports research aimed at identifying and validating molecular determinants of basal-squamous pancreatic cancer, a disease subtype associated with poor prognosis and resistance to standard gemcitabine...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Virginia a $161,500 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, with completion targeted for May 31, 2028. This research initiative develops innovative methodologies for classifying heterogeneous circulating tumor cells (CTCs) from pancreatic ductal adenocarcinoma (PDAC) patients by leveraging single-cell deformability as a complementary metric to traditional...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded University of California, San Diego a $410,115 project grant under the Cancer Biology Research program (CFDA 93.396) beginning August 1, 2025, with completion scheduled for July 31, 2027. This research initiative develops improved preclinical models for pancreatic ductal adenocarcinoma (PDAC) by incorporating three-dimensional high-density type I collagen into tumor modeling systems. The project addresses a...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Emory University a Project Grant of $602,170 under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) effective June 2, 2026, through May 31, 2031. This award supports the development and validation of biomimetic migrating nanoparticles designed to target tumor stroma and neural invasion in pancreatic cancer treatment. The research involves engineering hyaluronic acid nanoparticles (HANPs) conjugated...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Pittsburgh a Project Grant totaling $408,829 under the Cancer Treatment Research program (CFDA 93.395) to investigate lipogenesis-mediated resistance to cytotoxic therapy in pancreatic ductal adenocarcinoma (PDAC). The award, effective May 25, 2026 through April 30, 2028, supports fundamental research aimed at characterizing how tumor cells use de novo lipid production to escape cell death mechanisms and evade...
Florida State University's Sponsored Research Administration Division received a $567,264 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded June 10, 2026, with a completion date of May 31, 2031. The award supports fundamental research investigating the role of cellular physical interactions in pancreatic cancer progression. Pancreatic ductal adenocarcinoma (PDAC) represents a critical research focus given the disease's 13% five-year overall survival rate—the lowest among all cancers. The project will deliver research products through two specific aims: (1) identification of ion and water channels regulating PDAC epithelial architecture changes that drive disease progression, revealing novel therapeutic targets, and (2) characterization of YAP's functional role in PDAC progression to guide development of YAP-targeted therapies. The research employs a unique organoid model developed from human normal pancreatic tissue, primary tumor samples, and metastatic lesions, combined with experimental and computational approaches to elucidate mechanisms underlying epithelial architecture transitions in PDAC. Expected deliverables include mechanistic insights into lumen structure disruption as a driver of disease progression, identification of ion and water channel targets for therapeutic intervention, and foundational knowledge to advance YAP-targeted therapeutic development. This project advances the Cancer Biology Research program's objective of providing fundamental information on cancer's cause and nature to improve prevention, detection, diagnosis, and treatment of neoplastic diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $567.3k | 6/11/26 |