Project Grant R01CA296078
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $2,970,010 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded on September 16, 2025, with completion targeted for August 31, 2029. The research initiative focuses on elucidating the tumorigenic mechanisms of somatic truncation mutations in KMT2D, which encodes the histone methyltransferase MLL4 (mixed-lineage leukemia 4), particularly as...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded The Leland Stanford Junior University a $635,340 Project Grant on May 4, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to support research extending through April 30, 2031. This award funds a functional genomic dissection project investigating lung cancer tumor suppressor pathways through an integrated approach combining genetically engineered mouse models, multiplexed CRISPR (Clustered...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $954,436 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on September 23, 2025, with a completion date of July 31, 2030. The award funds fundamental cancer research investigating the mechanisms by which chronic myeloid leukemia (CML) leukemia stem cells persist during tyrosine kinase inhibitor (TKI) treatment through their interaction...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Grant Award Summary Northwestern University received a $2.1 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), awarded September 23, 2025, with completion targeted for August 31, 2029. The project aims to determine genotypic, phenotypic, and evolutionary trajectories of treatment resistance to radiotherapy by analyzing matched pre- and post-radiotherapy genomes from patient tissue and patient-derived xenografts (PDXs)...
- Federal Grant Award Summary Award Details: Funding Agency: National Cancer Institute Federal Grant Program: Cancer Cause and Prevention Research (CFDA 93.393) Awardee: Northwestern University, Sponsored Research Division Total Obligated Funding: $645,460 Award Period: August 1, 2025 – July 31, 2030 Northwestern University will conduct a five-year research project to elucidate the mechanisms underlying nilotinib-induced artery disease (NIAD) and develop predictive tools to identify patients at...
- Federal Grant Award Summary The National Cancer Institute awarded The Washington University a $355,706 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2025, through May 31, 2030. The award funds fundamental research aimed at understanding the role of RAMS11 (RNA Associated with Metastasis 11), a long noncoding RNA (lncRNA), in non-small cell lung cancer (NSCLC) development and progression. The research addresses a critical knowledge gap in cancer biology...
- Federal Project Grant Summary Northwestern University, through its Sponsored Research Division, received a $1,453,656 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective September 1, 2025, with a completion date of August 31, 2030. The grant funds research investigating the role of adverse social-biological interactions in acute myeloid leukemia (AML) disparities. The project leverages the multi-institutional Chicago AML...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Washington University a Project Grant totaling $425,088 (Award Date: May 1, 2026; Completion Date: April 30, 2031) under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a comprehensive comparative analysis of lung cancer care and outcomes between Medicare Advantage (MA) and Traditional Medicare (TM) beneficiaries. The research will leverage large national databases to create representative...
- Federal Grant Award Summary Northwestern University received a $495,374 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on August 25, 2025, with completion targeted for July 31, 2030. The award funds fundamental research investigating the human papillomavirus (HPV) life cycle and the role of R-loops (ribonucleic acid-deoxyribonucleic acid hybrid structures) in viral replication and transcription. The research examines how HPV...
Northwestern University's Sponsored Research Division received a $631,487 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393) effective June 1, 2026, through May 31, 2031. This award supports a comprehensive research initiative investigating the mechanistic underpinnings of LKB1 (STK11) mutation-driven lung cancer and therapeutic resistance mechanisms. The research deliverables include: (1) mechanistic studies defining how LKB1 loss regulates the HDAC3/NKX2-1 complex function in lung cancer cells; (2) preclinical testing of combination treatment efficacy using KRAS pathway inhibitors and entinostat in LKB1-mutant lung cancer models; and (3) characterization of how KRAS pathway inhibitors impact the HDAC3/NKX2-1 regulatory node to control tumor growth. The research employs integrated genomics and mass spectrometry methodologies utilizing both in vitro lung cancer cell lines and in vivo mouse models to achieve these objectives. The use of mouse models is essential for evaluating LKB1 pathway function in an intact immune system context, as this pathway demonstrates differential behavior between in vitro and in vivo environments. These research outcomes are intended to advance the understanding of genetic and therapeutic mechanisms modulating HDAC3 complex function in lung tumor biology and to generate evidence supporting improved therapeutic options for patients with LKB1-mutant lung cancer.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $631.5k | 5/28/26 |