Project Grant R01CA295677
- Federal Project Grant Award Summary The University of Vermont & State Agricultural College received a $129,624 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective July 14, 2025, through June 30, 2027. This award supports research investigating adipose tissue (AT) as a novel facilitator of tumor growth and cancer cachexia (CC) in lung cancer patients. The funded research develops and utilizes an improved...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Dayton a $451,131 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) on July 9, 2025, with a completion date of May 31, 2028. Led by Principal Investigators Shawn Swavey (Department of Chemistry) and Kristen Krupa (Department of Chemical and Materials Engineering), this project will develop endoplasmic reticulum (ER)-targeting boron dipyrrin (BODIPY) fluorescent imaging agents...
- Federal Grant Award Summary The National Cancer Institute awarded a Project Grant of $729,587 on August 21, 2025, to The Regents of the University of California, San Francisco under the Cancer Treatment Research program (CFDA 93.395) to develop a personalized voxel-wise prediction model for brain metastases using multi-parametric magnetic resonance imaging. The research deliverable addresses a significant clinical challenge in non-small cell lung cancer adenocarcinoma patients by creating a...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $584,510 to the University of Colorado-Denver on September 12, 2025, under the Cancer Biology Research program (CFDA 93.396) to support the development and implementation of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. Through the Human Immune Monitoring Shared Resource (HIMSR) at the University of Colorado Cancer Center, this funding supports a...
- Federal Grant Award Summary The National Cancer Institute awarded a $409,141 Project Grant to the University of California, Davis, effective June 1, 2026, through May 31, 2028, under the Cancer Detection and Diagnosis Research Program (CFDA 93.394). The grant supports research and development of perfusion computed tomography (CT) imaging technology as an alternative diagnostic tool for liver radioembolization treatment planning. The project aims to validate contrast-enhanced perfusion CT as a...
- Federal Grant Award Summary Virginia Polytechnic Institute & State University (Virginia Tech) received a $411,583 Project Grant award from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective August 1, 2025, through July 31, 2027. This award supports the development and validation of a computational model that characterizes the relationship between perivascular spaces and interstitial fluid flow in glioma invasion. The project...
- Federal Project Grant Award Summary The University of Virginia received a $192,888 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025, through August 31, 2028. This award supports research aimed at identifying causal genetic variants associated with colorectal cancer risk and elucidating their mechanistic pathways. The project employs normal colon organoids as a novel research platform to distinguish true...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1.22M to the University of Massachusetts Boston under its Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, through July 31, 2028. This project grant supports fundamental research to advance understanding of extracellular vesicles (EVs)—cell-derived, membrane-bound structures that carry biomolecules and serve as circulating biomarkers for disease diagnosis and therapeutic delivery. The research...
- Federal Grant Award Summary The National Cancer Institute's Cancer Treatment Research program (CFDA 93.395) awarded a $638,120 Project Grant to The Trustees of Columbia University in the City of New York (Health Sciences Division) beginning August 1, 2025, with an ultimate completion date of May 31, 2030. This award supports research to develop and evaluate improved methods of cancer treatment through laboratory and clinical investigation focused on neoantigen cancer vaccines using microbial...
- Federal Grant Award Summary The University of North Texas received a $148,500 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), with an award date of September 5, 2025, and completion date of August 31, 2027. The research project evaluates the role of extracellular vesicles (EVs) in tumor microenvironment modulation, specifically investigating how tumor-derived EVs contribute to immunosuppression in non-small cell lung cancer...
Federal Grant Award Summary The University of Vermont received a $595,012 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) effective April 13, 2026, through March 31, 2031. The award supports the development and refinement of an integrated image-enabled computational model for optimizing intratumoral cisplatin delivery in non-small cell lung cancer (NSCLC) treatment. The research leverages dual-energy computed tomography (DECT) imaging to identify regional variations in microvascular perfusion within tumors, enabling personalized dosing calculations that account for tumor volume, morphology, and drug retention patterns. This computational approach aims to improve treatment efficacy while minimizing systemic adverse effects associated with intravenous cisplatin administration. The project builds on preliminary clinical validation demonstrating 72% accuracy in predicting tumor response using the computational dosing model, which is licensed through industry partner Quantitative Imaging Solutions. Key deliverables include advancing the understanding of drug retention variability (currently ranging from 30-70% across treatment cycles) and developing enhanced algorithms that correlate perfusion characteristics with therapeutic outcomes. The research addresses a significant clinical need for approximately 120,000 annual deaths from stage IV NSCLC in the United States, with potential applications extending to improved central airway obstruction treatment and enhanced immunotherapy response in untreated lesions.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $595.0k | 4/13/26 |