The University of Chicago received a $1,396,152 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) to examine the role of BNIP3 and mitophagy in muscle atrophy during cancer cachexia in pancreatic ductal adenocarcinoma (PDAC). The research aims to provide mechanistic insights into how BNIP3 promotes myofiber atrophy and how muscle atrophy may contribute to PDAC progression and serve as a biomarker for early-stage disease. The award, effective from December 2024 through November 2029, supports the use of genetically engineered mouse models and analysis of human PDAC patient muscle samples to address these research objectives.
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