Project Grant R01CA285582

Award Date 12/11/24
Completion Date 12/31/29
Dollars Obligated $621K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
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This Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides approximately $693,781 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research aimed at harnessing mutant IDH1 as a therapeutic target for liver cancer, brain tumors, and other solid malignancies. The research program has two key components: Further studying how mutations in the IDH1 gene and the resulting metabolite...
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This Project Grant award from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) provides $1,181,683 to the Dana-Farber Cancer Institute in Boston, MA to conduct research aimed at enhancing immune checkpoint blockade responsiveness and tertiary lymphoid structure formation through CD4+TFHx13 CAR-T cells to achieve cures for clear cell renal cell carcinoma (CCRCC). The research will involve experimental design and computational analysis of...
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This Project Grant award of $620,820 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is focused on investigating mechanisms of immune therapy resistance in cancer. The primary recipient, The General Hospital Corporation (dba Massachusetts General Hospital), is conducting research to understand how the transcription factor CREB5 drives tumor resistance to anti-PD-1 immunotherapy.

Specifically, the research aims to: 1) decipher the molecular mechanisms governing CREB5 regulation and transcription, 2) identify CREB5-interacting proteins that drive collagen matrix deposition, and 3) elucidate how LAIR1-collagen sensing inhibits anti-tumor immune responses. This work builds on preliminary findings that CREB5 overexpression leads to increased collagen production, which triggers inhibitory signaling through the LAIR1 receptor on immune cells. The grant period runs from December 2024 to December 2029.

The General Hospital Corporation has also issued a sub-award of $139,000 to the Dana-Farber Cancer Institute to collaborate on this research project, which will help advance the understanding of tumor-intrinsic mechanisms of immunotherapy resistance.

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