Project Grant R01CA293642

Award Date 4/1/25
Completion Date 3/31/30
Dollars Obligated $690K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
New York, USA
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  1. Define the molecular and immune features associated with the progression and recalcitrance of STK11/KEAP1 co-mutant NSCLCs.
  2. Determine how the individual loss of STK11 or KEAP1 regulates invasion, tumor growth, and ferroptosis in preclinical models.
  3. Establish the efficacy of targeting the ferroptosis regulator SCD1, potentially in combination with ferroptosis inducers, to overcome resistance to chemotherapy or immunotherapy in STK11/KEAP1 co-mutant NSCLCs.

The award period runs from April 1, 2025 to March 31, 2030 and is being provided to the Icahn School of Medicine at Mount Sinai, a private research university in New York.

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