The National Cancer Institute (NCI) awarded a $568,151 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to the Regents of the University of Michigan to develop a real-time functional photoacoustic imaging platform. The objective is to leverage advanced photoacoustic imaging techniques and biocompatible hydrogel nanoprobes to enable sensitive detection of prostate cancer tumors and accurate characterization of cancer aggressiveness through quantitative assessment of imaging biomarkers. The research aims to optimize the photoacoustic nanoprobes for chemical imaging of the tumor microenvironment, assess the performance in clinically relevant mouse models, and develop a multivariate strategy for prostate cancer diagnosis and prognosis. Successful completion of this 5-year project is expected to produce a prototype photoacoustic imaging platform that can be integrated with transrectal ultrasound guided biopsy procedures to improve core yields and reduce false negatives in evaluating prostate cancer aggressiveness.
Generated 3/4/25, 3:57 AM