This Project Grant award of $1,349,322, provided by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research), supports research at the University of Pittsburgh to study how the Kaposi's sarcoma-associated herpesvirus (KSHV) manipulates cellular metabolic pathways and the S-adenosylmethionine (SAM) cycle to maximize both latent and lytic viral infections. The researchers aim to identify KSHV-regulated N6-methyladenosine (m6A) modifications on cellular mRNA that reprogram the SAM cycle, and delineate the mechanisms by which KSHV hijacks the m6A writer protein METTL16 to regulate these processes. This 5-year project, starting on January 1, 2025, leverages a multidisciplinary team's expertise in KSHV biology, cancer pathology, metabolism, proteomics, and computational biology to elucidate novel mechanisms regulating KSHV latency and lytic replication, with the goal of identifying new therapeutic targets for KSHV-induced cancers. The University of Southern California has been awarded a $291,000 sub-grant under this Project Grant to contribute their expertise in relevant research areas.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 2/12/25 | ||
| Not listed | $674.7k | 12/24/24 | ||
| Not listed | $674.7k | 12/24/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
2010291S | University Of Southern California | Project Grant R01CA291244 | $110.2k | 2/17/25 |