This $164,500 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to identify targetable mechanisms of S100A9-mediated brain metastasis in EGFR-mutant lung cancer. Led by researchers at Columbia University's Health Sciences Division, the project aims to investigate the epigenetic regulation and nuclear functions of S100A9 in promoting brain metastasis. Specifically, the researchers will employ advanced epigenomic profiling and genome...
This $678,879 Project Grant awarded by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) supports research by Cold Spring Harbor Laboratory (CSHL) to investigate a novel epigenetic vulnerability in glioblastoma (GBM), the most common and deadly adult primary brain cancer. The key focus is elucidating the mechanism by which targeting the chromatin regulator BRD8 can re-establish p53-mediated tumor suppression in GBM lacking p53 mutations,...
This federal Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) provides $127,952 to George Washington University to explore the role of the enzyme HDAC11 in liver cancer and evaluate the potential of HDAC11 inhibitors as a cancer treatment approach. The research aims to understand how HDAC11 promotes hepatocellular carcinoma through its interaction with the splicing factor SF3B2, and to test the effects of HDAC11-specific small molecule...
This $3,787,956 federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to New York University School of Medicine will fund research to understand and target replication stress in small cell lung cancer (SCLC). The project aims to investigate how the SLFN11 gene and replication stress response pathways influence SCLC chemosensitivity, with the goal of developing novel strategies to overcome acquired chemoresistance. The research will leverage...
This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) in the amount of $954,000.00 will support research to understand how aging promotes tumor growth in glioblastoma, a highly lethal form of brain cancer. The University of Pittsburgh will leverage insights from aging in the nervous system and the molecular circuitry of cancer stem cells to investigate the metabolic alterations within the aging tumor microenvironment. The goal is to derive...
The National Cancer Institute (NCI) awarded a $730,400 Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research. The five-year grant, running from December 1, 2024 to November 30, 2029, will support research to determine how specific configurations of the tricarboxylic acid (TCA) cycle metabolic pathway contribute to the development and maintenance of treatment-resistant lung adenocarcinoma (LUAD) cell states. The research aims to...
This $401,115 federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports Georgetown University's development and evaluation of a 3D bioengineered microfluidic platform to study the mechanisms underlying Ewing sarcoma bone metastasis. The goal is to create an in vitro model that closely mimics the bone microenvironment to enable high-throughput genetic screening of Ewing sarcoma cells with high metastatic potential. This 2-year project aims...
This Project Grant award, provided by the National Cancer Institute under the Cancer Biology Research (CFDA 93.396) program, supports scientific research aimed at understanding the fundamental biological mechanisms underlying cancer development, progression, and potential treatment interventions. The award of $569,441 will fund a 5-year project to investigate the regulation of nuclear AKT by p53, MDM2, and phosphoinositide lipids, and their roles in oncogenic transformation and tumor...
This federal Project Grant award, provided by the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), supports research to investigate the epigenetic regulation of T cell metabolism and immune functions by the protein SIRT6. The $219,491 award, effective from January 1, 2025 to December 31, 2026, will be conducted by the Mayo Clinic Jacksonville, a nonprofit healthcare organization. The research aims to understand how SIRT6 regulates chromatin remodeling and...
This National Cancer Institute (CFDA 93.396 Cancer Biology Research) Project Grant award to the Icahn School of Medicine at Mount Sinai in the amount of $560,297 will fund a 5-year research project to functionally characterize "oncofetal stem cells" in colorectal cancer (CRC). The project aims to: Generate reporters to track the dynamics of CRC stem cell populations, including oncofetal stem cells and LGR5+ cancer stem cells. The researchers will then use these reporters coupled to a...