This $608,491 Project Grant award from the National Cancer Institute's Cancer Biology Research program (CFDA 93.396) supports research at Northwestern University to investigate the role of mitochondrial metabolism and the TCA cycle enzyme malate dehydrogenase 2 (MDH2) in lung tumor growth and development. The research aims to understand how MDH2 and mitochondrial NAD+ regeneration impact tumor initiation, progression, and hypoxic adaptation in a mouse model of lung adenocarcinoma. Complementary studies will assess the necessity of MDH2 for normal alveolar epithelial cell function. This multi-year research project seeks to enhance the understanding of mitochondrial metabolism's importance in supporting lung tumor growth and normal lung cell biology.
Generated 3/4/25, 5:43 AM