This $717,667 federal Project Grant awarded by the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to the Icahn School of Medicine at Mount Sinai aims to develop an AI-enabled, stroma-weighted automated grading system (SWAG) to improve risk stratification and early detection of lethal prostate cancer phenotypes in Black men. The key objectives are to: 1) Annotate H&E and multiphoton microscopy/second harmonic generation images to develop the AI-powered SWAG system for prostate cancer risk prediction, and 2) Define and validate the molecular drivers of racial disparities in prostate cancer outcomes using spatial transcriptomics and multiplexed CRISPR approaches. This 5-year project (3/12/2025 - 2/28/2030) seeks to introduce innovative, label-free imaging techniques and advanced data analytics to enhance early detection and prognostication of aggressive prostate cancer, particularly in the Black patient population.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $717.7k | 3/12/25 |