The University of Texas Southwestern Medical Center (UT Southwestern) received a $544,478 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to conduct research aimed at "Decoding the Metabolic Routes of Purine Nucleotides in Cancer." The grant, awarded on December 1, 2024, supports a 5-year study to investigate the mechanisms by which oncogenic signaling regulates purine nucleotide synthesis pathways, the influence of dietary nucleotides on tumor metabolism and growth, and the metabolic flexibility between de novo and salvage purine synthesis in tumors. The research seeks to expand the understanding of purine metabolism in cancer and identify new strategies to effectively target purine supply mechanisms to eradicate tumor growth.
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