Project Grant R01CA288236

Award Date 4/18/25
Completion Date 3/31/30
Dollars Obligated $398K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Houston, TX 77204, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) is focused on conducting research to evaluate the role of metabolism in persister cell survival within mammalian cell populations. The total funding amount is $398,282 and the award period is from April 18, 2025 to March 31, 2030.

The key products and services to be delivered under this grant include:

  • Verifying the hypothesis that persister cells have a transient metabolic state characterized by increased oxidative phosphorylation and decreased anabolic activities, using various experimental techniques such as persister assays, proteomics, metabolomics, and fluorescence microscopy.
  • Uncovering the active metabolic pathways and their significance in persisters through a combination of experimental data and mathematical modeling approaches.
  • Disrupting the targeted metabolic pathways through genetic and chemical means to test the hypothesis.

The research is expected to have a substantial impact by providing insights into the metabolic properties of persister cells, which are thought to underlie the recurrence of tumors and the emergence of drug-resistant mutants. The methodology developed under this grant will also be applicable to persister cells in diverse mammalian and microbial organisms.

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