Project Grant R01CA285925

Award Date 8/6/24
Completion Date 7/31/29
Dollars Obligated $679K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Milwaukee, WI 53226, USA
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This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $444,569 to Beth Israel Deaconess Medical Center, Inc. to develop innovative models for hormone receptor positive (HR+) breast cancer using patient-derived organoids and cancer-associated fibroblasts. The goal is to address the lack of representative preclinical models for recurrent and metastatic HR+ breast cancer, which accounts for the majority of breast cancer deaths. The...
This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) provides $447,340.00 to the University of Miami to investigate epigenetic mechanisms that contribute to endocrine-resistant breast cancer. The study aims to identify vulnerabilities in the COREST-SWI/SNF axis, a key signaling pathway involved in endocrine therapy resistance, with the goal of developing new targeted treatments to improve survival for patients with metastatic,...
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This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides funding to The Medical College of Wisconsin, Inc. to implement an intervention targeting high-risk breast cancer patients who have poor adherence to oral endocrine therapy. The $678,927 award, effective August 6, 2024 through July 31, 2029, will support a randomized study to assess the impact of routine symptom monitoring and management with clinical pharmacist-led follow-up on patient adherence to oral endocrine therapy. The study will also explore the intervention's impact on patient-reported symptoms and potential mechanisms for improving adherence, such as self-efficacy, team communication, and social support. If successful, this intervention has the potential to improve care for thousands of women with hormone receptor positive breast cancer who struggle with endocrine therapy adherence.

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