The University of Southern California (USC) Department of Contracts and Grants has been awarded a $613,220 Project Grant by the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research (CFDA 93.393) program. The grant supports a comprehensive investigation into the contribution of germline copy number variations (CNVs) to the susceptibility and aggressiveness of prostate cancer in men of African and European ancestry.
The research leverages existing genome-wide association study (GWAS), whole-exome sequencing (WES), and whole-genome sequencing (WGS) data from large-scale studies to impute common CNVs, detect rare coding CNVs, and comprehensively assess CNVs of all sizes and frequencies across the genome. The project aims to evaluate the associations between CNVs and risk of total and aggressive prostate cancer, as well as the joint contribution of CNVs and single nucleotide variants (SNVs) on prostate cancer risk and disease aggressiveness across diverse populations. The findings from this 5-year project are expected to advance the understanding of genetic factors underlying prostate cancer and improve risk stratification strategies.
Generated 3/4/25, 5:19 AM