This federal Project Grant award from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) in the amount of $681,116 aims to evaluate the safety and efficacy of a novel alpha-emitter radiopharmaceutical therapy (ARPT) for the treatment of osteosarcoma, a highly radioresistant form of bone cancer. The project, led by The Johns Hopkins University, will utilize the alpha-particle emitting isotope actinium-225 conjugated to an anti-GD2 antibody (225Ac-hu3F8) to target and treat metastatic osteosarcoma in a naturally occurring large animal model (client-owned dogs). Key objectives include determining the maximum tolerated absorbed dose, assessing treatment efficacy at the maximum tolerated dose, and developing a pharmacokinetic/dosimetry model to guide optimization of ARPT for future human clinical trials in osteosarcoma patients. This research aims to develop a fundamentally new therapeutic approach for this challenging cancer, for which no new treatments have been identified in over four decades.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $681.1k | 5/22/24 |