Project Grant R01CA285517
Award Date 8/22/25
Completion Date 7/31/29
Dollars Obligated $3.1M
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Arizona, USA
Similar Awards
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $1,623,261 to Case Western Reserve University to conduct a clinical trial and develop novel molecular technologies for early detection and prevention of esophageal adenocarcinoma. Specifically, the project aims to: 1) demonstrate the efficacy of a non-endoscopic, biomarker-based approach to detect Barrett's esophagus, a precursor to esophageal cancer, in a population...
- This Cooperative Agreement award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $323,226.00 to the Regents of the University of Michigan to develop natural products that target IL-8 signaling and intercept the progression from Barrett's esophagus to esophageal adenocarcinoma. The project aims to understand the fundamental biology underlying this cancer progression and identify new prevention and treatment approaches. The award term is from Aug 1,...
- This federal Project Grant award of $680,334.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to elucidate the molecular mechanisms and cellular players driving age-associated pro-tumoral myelopoiesis. The research will involve high-dimensional profiling of tumors from an early-stage lung cancer patient cohort, multi-omics phenotyping of myeloid cells and progenitors from young and aged patients and healthy donors, as well as complex bone marrow experiments. The...
- This Project Grant award of $684,877 from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) will support a multi-scale analysis of the Bacillus Calmette-Guerin (BCG) resistant tumor microenvironment in non-muscle invasive bladder cancer (NMIBC). The study aims to generate a comprehensive molecular atlas of the NMIBC tumor microenvironment, using matched single-nucleus RNA and ATAC sequencing, as well as spatial sequencing, across 36 samples....
- This federal Project Grant award of $930,500 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research by the University of Arizona to understand the biological mechanisms underlying loss of the Y chromosome (LOY) in cancer, with a focus on bladder cancer. The key products and services to be delivered under this multi-year award (Sep 2025 - Aug 2032) include: Identifying new genes and biomarkers related to bladder cancer growth, metastasis, and patient outcomes...
- This $183,494 Project Grant award from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) will support the development of the GLYCO-MAP platform. GLYCO-MAP is a high-throughput multiplexed system for profiling antibodies against glycosylated mucin proteins, which are dysregulated in cancer and can serve as biomarkers for early cancer detection. The project will leverage glycoengineered cell lines to produce well-defined homogeneous glycostructures,...
- This $749,901 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) federal grant program, is funding research to elucidate the origins of mutational landscapes in cancer. The University of Arkansas for Medical Sciences (UAMS) is the prime recipient, with sub-awards to the University of South Florida and University of California, San Diego. The research aims to characterize the DNA lesion landscape and link...
- This federal Project Grant award of $3,201,530.00 from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) supports research by the Sloan-Kettering Institute for Cancer Research to investigate the mechanisms underlying extrachromosomal DNA (ecDNA) segregation and repair in cancer. The research aims to understand how the circular topology of ecDNA affects its function and maintenance, including exploring the role of RNA-dependent physical tethering to mitotic...
- This Project Grant award of $734,435.00 from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) aims to advance cancer treatment research for acute myeloid leukemia (AML). The primary recipient, Beckman Research Institute of the City of Hope, will conduct research to investigate how inhibiting the ADSS2 enzyme can sensitize drug-resistant AML to BH3 mimetic therapies. The research will use patient-derived xenograft models to understand the molecular mechanisms underlying...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,625,853 to New York University (NYU) to conduct research aimed at understanding the fundamental biological mechanisms underlying cancer development, progression, and potential interventions. The project will leverage advanced 3D chromatin analysis techniques to map and characterize "3D regulatory hubs" - DNA elements that interact with multiple loci and coordinate...
This federal Project Grant award of $3,130,492.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Arizona State University (ASU) to study the ecology of Barrett's Esophagus (BE), a precursor to esophageal adenocarcinoma. The research aims to develop computational methods to analyze the spatial distribution of cell types in BE biopsies, detect abnormal cell proliferation, and identify DNA content abnormalities that could predict progression to esophageal cancer. The award period runs from August 22, 2025 to July 31, 2029. This work seeks to improve clinical diagnosis and treatment of BE patients at risk of developing esophageal cancer.
Generated 10/14/25, 5:34 AM
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.1m | 8/22/25 |