The National Cancer Institute (NCI) awarded The University of Texas MD Anderson Cancer Center a 5-year, $686,919 Project Grant under the Cancer Biology Research program (CFDA 93.396) to elucidate the role of three-dimensional (3D) chromatin architecture in T cell ferroptosis and its impact on renal medullary carcinoma (RMC). The research aims to:
- Establish the connection between altered chromatin architecture and the molecular pathway linking sickle cell disease (SCD) and RMC tumorigenesis;
- Investigate the 3D genomic mechanisms driving ferroptosis in CD8+ T cells in SCD; and
- Assess the significance of ferroptosis and altered genomic architecture in CD8+ T cells on the RMC disease landscape.
The project will utilize high-throughput chromosome conformation capture (Hi-C) techniques to characterize 3D chromatin structures in CD8+ T cells from SCD patients versus healthy controls. It includes a sub-award to the University of Texas Health Science Center at Houston to provide genomics/epigenomics expertise and data analysis support for the 3D genome architecture work under Aim 2. The insights gained are expected to inform the development of more effective immunotherapies for this rare but aggressive form of renal cancer.
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