Project Grant R01CA283469
- This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $127,629 to Harvard T.H. Chan School of Public Health to elucidate the role of both germline and somatic human leukocyte antigen (HLA) variations in cellular immunity and the efficacy of immune checkpoint inhibitor monotherapy in patients with non-small cell lung cancer. The research aims to leverage multi-omic data (genetics, genomics, transcriptomics, proteomics) from over 80,000 NSCLC...
- The National Cancer Institute (NCI) awarded a $455,111 Project Grant under CFDA 93.393 "Cancer Cause and Prevention Research" to the Sloan-Kettering Institute for Cancer Research in New York. The 2-year grant, awarded on September 5, 2023, will support research to "Leverage the Hidden Genome to Recover the Missing Heritability of Cancer." The project aims to 1) estimate additional heritability that can be explained by the "hidden genome" (regions of unknown...
- This Project Grant award of $138,846 from the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) supports a research project to develop "wild-like" laboratory mouse models that better mimic the adult human immune system. The goal is to produce mice with a more mature immune profile, in contrast to the immature immune system typically seen in standard laboratory mice, to enable more accurate translation of cancer and immunotherapy research findings...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $680,334 in funding to the Icahn School of Medicine at Mount Sinai to investigate the cellular and molecular mechanisms driving age-associated pro-tumoral myelopoiesis. The 5-year research project aims to elucidate how aging of the immune system, independent of stromal age, promotes inflammation and tumor progression. The researchers will conduct high-dimensional profiling of...
- The National Cancer Institute (NCI) awarded a $162,486 Project Grant under the Cancer Research Manpower (CFDA 93.398) program to the Icahn School of Medicine at Mount Sinai (ISMMS) to investigate the role of the interferon gamma (IFNγ) signaling pathway in the lung tumor microenvironment and its impact on tumor immunity. The project aims to deconvolute how various components of the IFNγ pathway, including the negative regulator SOCS1, influence immune cell infiltration and response to immune...
- This federal Project Grant award of $216,460 from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) to Case Western Reserve University aims to understand the mechanisms through which the EGFR L858R mutation in lung cancer generates an immunogenic neoantigen that provokes T cell-mediated anti-tumor immunity. The research project will fully characterize the EGFR L858R-derived neopeptide and its ability to activate T cells, utilizing techniques such as HLA...
- The University of Southern California received a $650,450 Project Grant from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) to develop a novel lung cancer immunotherapy product. The grant will fund the translational development of a tumor-specific T cell receptor-engineered CD4+ T cell product targeting the CT83 cancer-testis antigen, which is expressed in 40-60% of non-small cell lung cancers. The project aims to improve the therapeutic potential of this...
- This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) will provide $368,288 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research aimed at understanding molecular mechanisms contributing to disparate lung cancer outcomes experienced by patients of African ancestry. The research project will: 1) Determine how EGFR signaling differs based on patient genetic ancestry, 2) Quantify the interplay...
- The National Cancer Institute awarded a $148,050 Project Grant under the Cancer Research Manpower federal grant program (CFDA 93.398) to Weill Medical College of Cornell University. The grant supports research to study the role of the APOBEC3 family of cytosine deaminases in driving genomic instability and mutagenesis in lung cancer. The project aims to identify the specific APOBEC3 enzymes responsible for lung cancer mutagenesis and develop novel tools to measure APOBEC3 activity. This research...
- This federal Project Grant award of $166,800.00 from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) supports research at Pennsylvania State University's Milton S. Hershey Medical Center to investigate a novel combination therapy approach for an aggressive subtype of lung adenocarcinoma. The research aims to characterize how the loss of the MTSS1 protein impacts the tumor immune microenvironment in SMARCA4-mutant lung adenocarcinoma, and evaluate the...
IMMUNOGENETIC DETERMINANTS OF CANCER RISK - PROJECT SUMMARY IT HAS BEEN SHOWN THAT VARIATION IN CANCER RISK IS INFLUENCED BY MUTATIONS THAT MAY BE INHERITED, CAUSED BY ENVIRONMENTAL FACTORS SUCH AS SMOKING AND ULTRAVIOLET EXPOSURE, OR RESULTING FROM RANDOM DNA REPLICATION ERRORS. HERE WE PROPOSE A NOVEL FACTOR IN CANCER RISK, WHICH IS RELATED TO THE GENETIC DIVERSITY OF THE IMMUNE SYSTEM ACROSS HUMANS AND ITS ABILITY TO DETECT AND ELIMINATE EARLY CANCERS. IMMUNOSURVEILLANCE IS THE CONCEPT THAT THE IMMUNE SYSTEM ACTS AS A SURVEILLANCE SYSTEM TO DETECT AND DESTROY NEOPLASTIC CELLS BEFORE THEY PROGRESS TO A DETECTABLE MALIGNANT CANCER. THIS PROCESS RELIES ON T CELLS, WHICH RECOGNIZE TUMOR MUTATION-DERIVED NEOANTIGENS PRESENTED BY THE HUMAN LEUKOCYTE ANTIGEN (HLA) MOLECULES ON THE CELL SURFACE, RESULTING IN TUMOR- KILLING. WHILE HLA GENES ARE AMONG THE MOST POLYMORPHIC GENES IN VERTEBRATES, INCLUDING HUMANS, AND ARE ASSOCIATED WITH SEVERAL INFECTIOUS DISEASES AND CAN ALSO INCREASE THE RISK FOR AUTOIMMUNITY, OUR PRELIMINARY ANALYSIS SUGGESTS HLA DIVERSITY INFLUENCES CANCER RISK. THE GOAL OF THIS PROPOSED RESEARCH IS TO STUDY THE CONTRIBUTION OF IMMUNOGENETICS ON THE EFFICIENCY OF TUMOR IMMUNE SURVEILLANCE AND ITS ULTIMATE EFFECT ON CANCER RISK. OUR PRELIMINARY ANALYSIS DEMONSTRATES AN ASSOCIATION BETWEEN HLA HOMOZYGOSITY AND INCREASED RISK OF CANCER IN LUNG CANCER. USING LARGE PROSPECTIVE COHORTS OF INDIVIDUALS WITH DEEP GENETIC AND PHENOTYPIC DATA, WE WILL INVESTIGATE THE RELATIONSHIP OF HLA DIVERSITY AND LUNG AND MELANOMA CANCER RISK AND THE INTERACTION OF HLA IMMUNOGENETICS WITH ENVIRONMENTAL RISK FACTORS. A MURINE CARCINOGEN INDUCED LUNG CANCER MODEL WILL OFFER VALIDATION OF CAUSALITY AS WELL AS MECHANISTIC INSIGHTS FOR THERAPEUTIC TARGETS. THE INSIGHTS GAINED FROM THESE STUDIES WILL POTENTIALLY IMPROVE PREDICTIVE CANCER RISK MODELS IN GERMLINE CARRIERS AND SUGGEST STRATEGIES FOR IMMUNE-MEDIATED CANCER PREVENTION.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $68.3k | 6/3/25 | ||
| Not listed | $614.5k | 4/23/25 | ||
| Not listed | $614.5k | 4/23/25 | ||
| Not listed | $674.8k | 5/29/24 | ||
| Not listed | $674.8k | 5/29/24 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
IF320761153940002S | The General Hospital Corporation | Project Grant R01CA283469 | $49.1k | 6/5/25 |