The National Cancer Institute (NCI) awarded a $632,319 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to the Van Andel Research Institute (VAI) located in Grand Rapids, Michigan. The funding supports a 5-year research project to investigate the mechanisms of DNA methylation signaling and dysregulation in colon cancer. The project aims to characterize the ubiquitin signaling network regulating DNA methylation inheritance, examine the role of the E3 ubiquitin ligase UHRF1 in driving DNA methylation changes and colon tumorigenesis, and explore non-canonical functions of UHRF1 in heterochromatic histone modification signaling. These studies seek to reveal fundamental causes and consequences of abnormal DNA methylation in colon cancer, with the goal of identifying novel approaches to enhance the efficacy of DNA hypomethylation therapy as a treatment strategy.
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