This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research program) provides $537,985 to the University of Texas MD Anderson Cancer Center to deeply characterize the location, distribution, and spatial functionality of microbes within the tumor microenvironment of primary pancreatic ductal adenocarcinoma (PDAC) tumors, as well as their influence on tumor growth, pre-metastatic niche formation, and liver metastasis. The research will utilize state-of-the-art microbial-host imaging, regional and single cell microbial-host sequencing, and in vivo mouse models to better understand the role of PDAC-associated microbes in driving cancer progression. The goal is to develop novel microbial modulation strategies that could improve outcomes for patients with this aggressive form of pancreatic cancer. The project will be conducted over a 5-year period from August 1, 2024 to July 31, 2029.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $538.0k | 7/31/24 |