This Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $667,485 to the University of California, San Diego to conduct a longitudinal study investigating the mechanisms underlying radiation-induced neurocognitive decline in patients with glioma. The study aims to: 1) Characterize neurocognitive heterogeneity and identify cognitive phenotypes in glioma patients before and after radiation therapy (RT); 2) Analyze biomarkers of...
This federal Project Grant award, titled "MONOSYNAPTIC TRACING DEFINES CIRCUIT CONNECTIVITY OF HUMAN HIGH-GRADE GLIOMA IN THE ADULT MOUSE BRAIN", was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $195,896 award will support research at the University of Pennsylvania to map the whole-brain inputs onto glioblastoma, a deadly form of brain...
This Project Grant award for $517,732.00 was provided by the National Cancer Institute (NCI) under the Cancer Treatment Research Federal Grant Program (CFDA 93.395). The grant supports research at the University of Colorado-Denver to investigate how endocrine therapies and radiation therapy can be used in combination to decrease the risk of brain metastases in younger women with aggressive forms of breast cancer. The key objectives are to: 1) determine how endocrine therapies and radiation...
This $665,435.00 Project Grant award from the National Cancer Institute's Cancer Research Manpower (CFDA 93.398) Federal Grant Program aims to develop a system capable of simultaneous multi-tracer Positron Emission Tomography (PET) imaging. The project will focus on enabling simultaneous PET imaging of multiple molecular probes by using tracers that emit both positrons and higher energy gamma photons. This will provide a more comprehensive understanding of biological processes in diseases like...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program, will fund research to target cell-scaffolding proteins that contribute to radioresistance in glioblastoma, an aggressive brain cancer. The $448,250 award to The Research Foundation For The State University Of New York, operating as Upstate Medical Center, will support a 2-year...
This federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) for $997,410 aims to develop MRI-based methods to detect and differentiate between the invasive neuronal (NEU) and glycolytic/plurimetabolic (GPM) subtypes of high-grade glioma (HGG) brain tumors. The goal is to leverage advanced diffusion MRI and deuterium MRI techniques to spatially resolve clusters of these invasive HGG subtypes, which have divergent microstructural,...
This Project Grant award of $597,766.00 from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) aims to develop novel methods for dual-tracer PET imaging to better characterize cancer using a long-axial field-of-view PET scanner called the PennPET Explorer. The key objectives are to: 1) Develop protocols to image fluoroglutamine (a research radiotracer) with FDG in breast cancer patients, enabling quantification of glutamine metabolism alongside glucose...
This National Cancer Institute (NCI) Project Grant Award under the Cancer Detection and Diagnosis Research program (CFDA 93.394) provides $666,670 to The Trustees of the University of Pennsylvania (Penn) from January 15, 2025 to December 31, 2028. The goal of this project is to develop methods and protocols to obtain high-quality dynamic information from both PET and spectral CT imaging modalities, and use dynamic spectral CT for PET kinetic modeling to reduce overall scan time to match existing...
This federal Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $696,133 to Northwestern University to develop non-invasive imaging technologies for tracking the behavior of neural stem cells in the brains of mice with breast cancer metastases. The goal is to create an ultra-sensitive imaging platform that can monitor the migration of these therapeutic stem cells within the brain environment, which is critical for advancing...
The National Cancer Institute (NCI), through the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded a $204,295 Project Grant (R21CA289166) to the University of Alabama at Birmingham (UAB) for the period of March 1, 2025 to February 28, 2027. The goal of this project is to integrate advanced molecular imaging techniques, including Positron Emission Tomography (PET) and Magnetic Resonance Imaging (MRI), to quantify the heterogeneity of HER2 expression and tumor vasculature in...
The federal Project Grant award R01CA275767, funded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports a research project to characterize synaptic density changes in the brain following radiation therapy. The $1,474,236 award, with a project period of Sep 2024 to Aug 2028, will utilize a novel PET tracer to quantify synaptic density changes in rodent models of both normal brain and brain tumors receiving targeted radiation therapy. The project aims to correlate these synaptic density changes with cognitive outcomes, with the goal of developing a non-invasive biomarker to monitor radiation-induced brain injury. The University of Pennsylvania will serve as a sub-awardee, focusing on the PET tracer synthesis and quantitative imaging analysis aspects of the project.