Project Grant R01CA138816

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $619,474 in funding to The Regents of the University of California, San Francisco (UCSF) to study the molecular mechanisms by which the cohesin protein complex regulates gene expression and neural wiring during brain development. The key objectives of this 5-year research project...

This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is providing $486,750.00 to the Sloan-Kettering Institute for Cancer Research, a non-profit organization, to conduct research on the molecular and cellular pathways that drive competency for human vagal neural crest specification. The research aims to fully characterize the population of cells that exhibits...

This federal Project Grant award of $329,834 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research at William Marsh Rice University to visualize and understand how extracellular morphogens, specifically the Nodal signaling pathway, shape embryonic development and cell fate patterning. The research will leverage CRISPR-edited human pluripotent stem cells to...

This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,226 to The Trustees of Columbia University in the City of New York to support research on the molecular mechanisms of Hedgehog (Hh) signal transduction in Drosophila. The research aims to elucidate how the Hh signaling pathway regulates the activity of the conserved transcription factors...

This federal Project Grant award from the Department of Health and Human Services National Institutes of Health National Cancer Institute, under the Cancer Cause and Prevention Research program (CFDA 93.393), provides $613,054 to St. Jude Children's Research Hospital Inc. to study the mechanisms by which transcription factors control different cell states in neuroblastoma, a high-risk pediatric tumor. The key objectives are to 1) interrogate how master transcription factors control the...

This federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $216,000.00 to the University of California, San Diego (UCSD) to elucidate the function of CTCF, a key protein involved in chromatin organization, in neural differentiation and neurodevelopment. The research will employ both 2D and 3D human cell models to examine the role...

This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), supports research to investigate the role of the developmental transcription factor ONECUT2 in the development of pineoblastoma, a rare type of childhood brain cancer. The $447,405 award to the University of Texas Southwestern Medical Center will fund a 5-year research project to determine if ONECUT2 is necessary for tumor development, how it...

This $242,310 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to investigate the effects of the NR2E1 genetic mutation on neurogenesis, neural stem cell biology, and associated behavioral outcomes. The research project aims to 1) assess how the I385T mutation in the NR2E1 gene impacts its ligand binding and...

Trustees of Tufts College, doing business as Tufts University School of Medicine, received a $453,750 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The funding will support research to define the potential of gene therapy to correct motor disabilities associated with CTNNB1 syndrome, a rare genetic disorder characterized by intellectual...

This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, aims to develop a hybrid differentiation strategy to efficiently derive region-specific cell populations, such as oligodendrocytes and neural crest progenitors, from human pluripotent stem cells. The $426,650 award, with a project period from June 1, 2025 to May 31, 2027, will...