This $425,847 Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under CFDA Program 93.213 - Research and Training in Complementary and Integrative Health aims to investigate the mechanisms and consequences of infraslow oscillations in sleep. The award is focused on determining how the dorsomedial medulla (DMM) and locus coeruleus (LC) regulate the infraslow power (ISP) rhythm and how this rhythm impacts sleep architecture, particularly the transitions between non-REM and REM sleep. The project will leverage neuropixels recordings, optogenetics, and computational modeling to advance the scientific understanding of infraslow brain dynamics and their role in sleep regulation. The award was made to the Trustees of the University of Pennsylvania, with sub-awards to the Regents of the University of Michigan and Trustees of the Colorado School of Mines to support the modeling and experimental components. The grant period runs from September 15, 2024 to May 31, 2029.
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