Project Grant R01AR088065
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $676,210 to The Washington University on August 5, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The recipient will conduct research into DNMT3A as an epigenetic transcriptional therapeutic target in femoroacetabular impingement (FAI) progression to osteoarthritis. FAI is a pre-arthritic hip condition affecting individuals aged 20 to 40; standard surgical treatment...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Carnegie Mellon University $486,545 on July 3, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and validate in vivo cartilage mechanics as a sensitive biomarker for early knee osteoarthritis detection. The research establishes a novel metric based on cartilage deformation and composition changes in response to common physical...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Ohio University $665,615 on August 15, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of a novel SIRT5 allele in osteoarthritis development. The research examines how altered SIRT5 activity in chondrocytes disrupts cellular metabolism and joint inflammation to increase osteoarthritis susceptibility. The recipient will conduct studies on a rare...
- The National Institutes of Health National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Duke University $124,875 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate muscle-to-bone communication during fracture repair and musculoskeletal regeneration. The research identifies pro-regenerative signals from injured muscle that orchestrate repair of both bone and muscle tissue. Preliminary findings...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $1.95 million Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 10, 2025, with an ultimate completion date of August 31, 2028. This research project investigates cellular stress mechanisms in osteoarthritis (OA) by examining the IRE1α-XBP1-NUPR1...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Northeastern University $652,195 on June 17, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to develop and test surface-modified, cartilage-targeting exosomes as non-viral gene delivery vehicles for osteoarthritis treatment. The project engineers charge-reversed cationic exosomes derived from mesenchymal stem cells, anchored with arginine-rich peptide motifs, to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded Pennsylvania State University (Penn State Milton S. Hershey Medical Center) $366,053 on June 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award funds research into adrenergic receptor signaling and GRK2-mediated desensitization in osteoarthritis pathogenesis, with the objective of identifying novel therapeutic targets for cartilage degeneration. The research...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded $421,367 to the University of Arkansas for Medical Sciences on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate microvascular integrity and its role in osteoarthritis development. The project examines how damage to blood vessels within the joint contributes to osteoarthritis pathology, specifically testing whether mechanical stress–induced...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded The Regents of the University of Colorado $578,289 on September 1, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846, Assistance Listing R01AR086835). The award funds translation and validation of DualMRI (Displacements Under Applied Loading by MRI), a noninvasive imaging method to measure articular cartilage biomechanics and predict pre-osteoarthritis pathogenesis in...
- Federal Project Grant Award Summary The University of North Carolina at Chapel Hill received a $361,300 exploratory/developmental Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective August 1, 2025 through July 31, 2027. The award supports research to identify novel signaling pathways and therapeutic targets for osteoarthritis (OA) disease...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health, awarded $675,318 to Duke University on August 20, 2026, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the relationship between obesity, cartilage mechanics, and osteoarthritis progression and the potential for weight loss and exercise interventions to reverse obesity-associated cartilage degeneration. The research evaluates how individuals with obesity exhibit altered articular cartilage structure, composition, and function indicative of early osteoarthritis, with elevated cartilage strains and reduced proteoglycan content compared to normal-weight participants. The project addresses whether weight loss and exercise can reverse degenerative cartilage changes through two aims: first, a cross-sectional evaluation of activity effects on cartilage degeneration in individuals with obesity, and second, a longitudinal assessment of weight loss or exercise interventions in insufficiently active individuals with obesity. The research will quantify in vivo cartilage strain distributions during treadmill stress testing and assess cartilage composition via T1Rho relaxation times and serum biomarkers of cartilage health. Duke University's Office of Research Administration, located in Durham, North Carolina, is the recipient. The period of performance runs through July 31, 2031. This is a Project Grant, the standard NIH research award mechanism.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $675.3k | 8/19/26 |