Project Grant R01AR087567
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the Regents of the University of Michigan a $1,317,880 Project Grant, effective September 19, 2025, through August 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This award funds research to elucidate the mechanisms of bone remodeling in response to high metabolic demands associated with aerobic exercise, addressing a...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded $637,567 to the Regents of the University of Michigan on September 19, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate the role of A20 and DREAM proteins in adipogenesis and systemic sclerosis (SSC). The research will be conducted through August 31, 2030, and aims to elucidate the mechanisms of myofibroblast...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant totaling $172,720 to the Regents of the University of Michigan for research activities spanning May 1, 2026 through April 30, 2031 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports fundamental research investigating neutrophil mitophagy (mitochondrial autophagy) in antiphospholipid syndrome (APS), an...
- Federal Project Grant Award Summary The University of Michigan received a $133,998 project grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 20, 2025, with completion anticipated by May 31, 2027. The research project, titled "CDK8 Inhibition as a Therapeutic Intervention for Ischemic Fracture Healing," investigates the development...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,083,807 Project Grant to The University of Kentucky Research Foundation beginning September 1, 2025, through May 31, 2030, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). This project investigates the regulation of myonuclear turnover dynamics in multinucleated skeletal muscle cells, addressing a fundamental gap in understanding...
- Federal Project Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded The Johns Hopkins University a $543,417 Project Grant effective June 1, 2026 through May 31, 2031 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research initiative focuses on promoting functional neuromuscular regeneration following chronic volumetric muscle loss (VML) in aged mice. The project will deliver three primary...
- Federal Project Grant Award Summary The University of Michigan received a Project Grant award of $409,941 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective March 5, 2026, with a completion date of December 31, 2030. The research program focuses on developing cellular reprogramming strategies and regenerative cell therapies to address chronic wound healing failures. The project centers on...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1.85 million Project Grant to the University of California, San Diego to conduct basic research on the role of lysine acetylation in skeletal muscle contractile function. Awarded on September 15, 2025, with completion targeted for August 31, 2028, this research project will produce scientific findings, peer-reviewed publications, and mechanistic data advancing understanding of...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the University of Nebraska Board of Regents $198,263 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) on September 5, 2025, with a completion date of August 31, 2027. This project grant supports research investigating the role of Mitsugumin 53 (MG53) in preventing disuse-induced muscle atrophy, a condition that accelerates age-related muscle...
- Federal Grant Award Summary The University of Arizona received a $1.89 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective July 1, 2026, through June 30, 2029. The award funds research investigating the molecular mechanisms underlying nebulin-associated congenital myopathies, specifically focusing on a novel class of dominant nebulin variants...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded the Regents of the University of Michigan a Project Grant totaling $630,434 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award, issued on June 16, 2026, with an ultimate completion date of March 31, 2031, funds fundamental research to understand the role of nuclear speckles and alternative splicing in muscle stem cell (MuSC) activation and regeneration across the human lifespan. Research will be conducted at the University of Michigan's Ann Arbor campus. The research delivers scientific knowledge and innovative methodologies through two primary aims: demonstrating how loss of the nuclear speckle scaffolding protein SRRM2 reduces the regenerative potential of muscle stem cells, and establishing how age-related oxidative stress attenuates nuclear speckles and RNA splicing that regulate muscle stem cell activation and muscle injury repair. The project employs novel transgenic animal models, sophisticated bioinformatics analysis, and innovative molecular tools to advance understanding of fundamental cell biology mechanisms relevant to regenerative medicine and musculoskeletal health across molecular, cellular, and tissue scales.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $630.4k | 6/18/26 |