Project Grant R01AR086796
- This federal Project Grant award of $196,460.00 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) will fund research into neuroimmune interactions and osteoarthritis pain. The University of Pittsburgh will use a novel microphysiological system to study the influence of inflammatory molecules from synovial-like tissue on innervating neurons, the role of chemokines like CXCL-1...
- This Cooperative Agreement award of $1,614,289.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop a novel composite digital endpoint that integrates measures of pain and gait patterns in individuals with knee osteoarthritis. The project, awarded to Trustees of Boston University, will employ a patient-centered approach to validate the technology, usability, and clinical utility of this...
- This $4,649,740.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund a study to understand inter-individual differences in the clinical trajectory of chronic musculoskeletal pain (CMSKP). The research aims to develop network representations of patients' lived experience of pain and functional state using language models and home-based videos, and to analyze state transitions in...
- This federal Project Grant award of $1,443,561.00 from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Drug Use and Addiction Research Programs (CFDA 93.279), supports a comprehensive study to characterize the role of the endocannabinoid system in inflammatory pain associated with osteoarthritis, acute post-surgical pain, and pain resolution or chronification in patients undergoing total knee arthroplasty. The research aims to determine how exogenous cannabis use...
- This $408,000 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program supports research to provide a comprehensive EEG profile of the cortical activity underlying the cognitive processing of the sensory-discriminative and affective-motivational dimensions of osteoarthritis knee pain. The research, conducted by Tarleton State University,...
- This federal Project Grant award for $5,057,591.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a 4-year prospective observational study at The Ohio State University to comprehensively characterize pain phenotypes, optimal pain treatment strategies, and predictive models of pain trajectories in emergency department (ED)...
- The federal Project Grant award titled "State-Dependent Control of Nociception in Opioid Circuits" is funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $667,349 grant aims to investigate the neurobiological mechanisms underlying pain perception and modulation, with a focus on endogenous opioid signaling in the ventrolateral periaqueductal gray...
- This $597,999 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research at the University of Pittsburgh focused on understanding the neuronal populations and mechanisms underlying mechanical allodynia, a common and debilitating condition of persistent pain. The 5-year project aims to identify the excitatory and inhibitory circuitry in the...
- This federal Project Grant award of $668,131 was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to Washington University in Missouri. The award is funding a research project titled "Mesolimbic Adaptations Underlying Altered Reward Sensitivity in Neuropathic Pain" with the goal of understanding the relationship between chronic neuropathic pain and altered dopaminergic function in the brain's reward system. The...
- This Project Grant award, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to develop computational tools to accurately predict and interpret different patterns of knee pain in patients with osteoarthritis. The $348,680 award, with a period of performance from Sep 26, 2024 to Aug 31, 2026, will enable researchers at the University of Arizona to: 1) Adapt a...
This federal Project Grant award of $4,899,748 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to elucidate the biopsychosocial mechanisms underlying individual differences in movement-evoked pain and functional impairment in knee osteoarthritis. The key products and services to be delivered under this grant include using concurrent ambulatory brain imaging and gait biomechanics to identify biological, psychological, and social factors contributing to the wide variation observed in knee osteoarthritis patients' walking pain and limitations on physical function. This interdisciplinary research aims to uncover novel treatment targets and enable more personalized approaches to managing this debilitating condition. The project will be conducted at the University of Pittsburgh over the award period from September 2025 to August 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $4.9m | 9/15/25 |