Project Grant R01AR086489
- This is a $5,318,433 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (part of the National Institutes of Health) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the role of the gut microbiome in contributing to individual differences in lumbosacral radicular pain, including pain severity, impact, and persistence after treatment. The research will leverage machine learning techniques to accurately...
- The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $529,616 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. to conduct research on the role of Notch signaling and fibrosis in treatment-resistant rheumatoid arthritis. The project aims to define the molecular mechanisms by which Notch signaling regulates transforming growth factor beta (TGF-β) signaling in...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a Project Grant of $158,912 under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), with a project period from November 1, 2025 to April 30, 2028. The goal of this research project is to elucidate the role of Wnt signaling in the mechanical maturation of tendon, which is...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $216,113 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Weill Medical College of Cornell University. The grant funding will support research to target the GDF15-GFRAL signaling pathway to prevent and treat cachexia (muscle wasting) in a mouse model of mitochondrial myopathy. Specifically, the research aims to determine if inhibiting the GDF15-GFRAL...
- The Department of the Army Medical Command awarded a $1,509,972 project grant to the Massachusetts General Hospital through the Military Medical Research and Development program. The grant will fund research from September 2022 through September 2025 to assess neuroinflammation in chronic pain using non-invasive microstructural imaging techniques. The Military Medical Research and Development program supports basic, applied, and advanced biomedical research with the goals of transforming...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,136,924 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the Rector & Visitors of the University of Virginia. The grant, awarded on July 1, 2025, is intended to support research on "Targeting Stage Specific Influxed Monocytes to Treat Acute and Chronic Back Pain". The project aims to use transgenic mouse models and a CCR2 antagonist to...
- The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $584,330 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research federal grant program (CFDA 93.846) to Northeast Ohio Medical University (Neomed) to conduct research on the role of mitochondrial DNA leakage in intervertebral disc degeneration and associated inflammation. The project aims to investigate whether oxidative damage to mitochondrial DNA leads to its fragmentation and...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $394,320 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to research how extracellular matrix (ECM) stiffness regulates the NLRP3 inflammasome in macrophages. The objective is to define the mechanisms by which ECM stiffness controls the NLRP3 inflammasome, which is relevant to...
- This $4.7 million project grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will support the development of electrophysiological and ultrasound quantitative biomarkers for myofascial pain syndrome. The grant to Beth Israel Deaconess Medical Center will establish the use of electrical impedance myography, myofiber threshold tracking excitability testing, and ultrasound shear wave elastography to assess differences between patients with active...
- The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $1,931,124 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to conduct research on the link between deranged gut homeostasis and the pathogenesis of fibromyalgia. The project, running from Sep 1, 2025 to Aug 31, 2028, aims to test the hypothesis that intestinal alkaline phosphatase (IAP) deficiency induces macrophage infiltration into the dorsal root ganglion and leads to fibromyalgia-like phenotypes in mice. The research will examine the role of IAP in regulating gut homeostasis and its potential as a therapeutic target for fibromyalgia, a chronic, debilitating, and often treatment-resistant pain condition.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/12/25 |