Federal Grant Award Summary

Northwestern University's Sponsored Research Division received a $524,335 Project Grant award dated June 5, 2026, from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award supports research through April 30, 2031, investigating the dynamic regulation of epidermal differentiation genes by cell-state-specific PBAF (polybromo-associated BAF) chromatin remodeling complex interactome. The research addresses molecular mechanisms governing the transition between gene repression and activation during epidermal differentiation, with direct implications for understanding and treating prevalent skin disorders including psoriasis, eczema, and cutaneous squamous cell carcinoma.

The project delivers fundamental research products focused on elucidating PBAF's functional switch from repressor to activator in differentiation regulation. Key deliverables include mechanistic characterization of upstream regulatory controls governing PBAF-PIAS1 (protein inhibitor of activated signal transducer and activator of transcription 1) association and dissociation, identification of downstream impacts of this protein interaction on epidermal differentiation, and investigation of ubiquitination-mediated regulation of protein stability. Research outputs will advance molecular understanding of epidermal homeostasis maintenance and contribute to development of targeted therapeutic strategies for skin diseases.