Project Grant R01AR085033
- This $375,100 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant funds a study to investigate the interplay between nucleic-acid-dependent phase separation and immune responses against cyclic GMP-AMP synthase (cGAS) in systemic lupus erythematosus (SLE). The research aims to determine how changes in the biophysical...
- This federal Project Grant award, valued at $127,273.00 and awarded on September 5, 2025, was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to study the role of the TFEB transcription factor in regulating the metabolic fitness and function of age-associated B cells (ABCs), a recently described B cell subset that accumulates during...
- This $256,808 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to better define the molecular mechanisms that cause and perpetuate systemic lupus erythematosus (SLE). The University of Washington is conducting this research, which focuses on analyzing altered mRNA splicing in SLE neutrophils and exploring the consequences of these splicing changes, including...
- This $366,639 federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) supports research to understand the mechanisms driving poor outcomes in women with dermatomyositis, a rare autoimmune disease. The key objectives are to: 1) Establish the Southern California Dermatomyositis Disease Network, a patient-centered registry to recruit diverse patients with dermatomyositis and...
- This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $704,424 to support research efforts to identify rare pathogenic variants and their functional consequences in Systemic Lupus Erythematosus (SLE). The key objectives are to: 1) apply whole genome sequencing on 127 SLE multiplex, simplex, and early-onset pediatric cases to define...
- This Project Grant award of $413,860 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to investigate the interactions between non-tuberculous mycobacteria (NTM) infections, specifically Mycobacterium abscessus (MAB), and the onset/flares of systemic lupus erythematosus (SLE). Using preclinical mouse models and an ex vivo model with alveolar-like macrophages, the researchers will examine the...
- This federal Project Grant award for $3,364,935.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) through the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to functionally and mechanistically characterize genetic factors that contribute to the development of systemic lupus erythematosus (SLE). The research aims to elucidate the role of autophagy, a cellular process, in the pathogenesis of SLE, particularly in immune cells and...
- This Project Grant award for $300,000 from the Department of Health and Human Services' National Institutes of Health (CFDA 93.310 Trans-NIH Research Support) to Brigham & Women's Hospital Inc. (a subsidiary of Partners Healthcare System) supports research on the role of activated neutrophils and T cells in the pathogenesis of systemic lupus erythematosus (SLE), lupus nephritis, and vasculitis. The research aims to investigate how immune cell abnormalities, specifically the generation of...
- This Project Grant award in the amount of $997,821.00 was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to support research on the "Pathogenic Role of Neutrophil Subpopulations in Lupus Nephritis". The primary awardee is the Trustees of Dartmouth College, a prestigious private research university, with sub-awards going to The Johns Hopkins University and Dartmouth-Hitchcock Clinic to assist with the research. The grant...
- This Project Grant award of $405,350.00 was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The research aims to characterize lipid droplets in macrophage subsets and determine if manipulating lipid droplet content can shift macrophage function, with the goal of uncovering new therapeutic targets for systemic lupus erythematosus (SLE). The award recipient is The...
This $544,689 federal Project Grant was awarded on August 6, 2025 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research at the University of Florida to investigate the diagnosis and treatment of diffuse alveolar hemorrhage (DAH), a severe lung complication that can occur in patients with systemic lupus erythematosus. The research aims to understand the genetic and molecular factors that make certain mouse strains susceptible to DAH, develop early diagnostic tests to detect DAH before onset of bleeding, and translate these findings to improve diagnosis and treatment of DAH in human lupus patients. The project is scheduled to run through June 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $5.9k | 9/8/25 | ||
| Not listed | $538.8k | 8/5/25 |