This federal Project Grant award of $465,008, provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), aims to study whether remote characterization of gene/module expression can promptly identify inter-individual variations in blood transcriptional trajectories following treatment with biologics in early psoriatic arthritis (PsA) patients. The research also seeks to...
The National Institutes of Health's National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded New York University School of Medicine $409,311.92 under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) from April 5, 2021 to January 25, 2022. The project grant funding supports research into the role of T follicular helper (TFH) cells in the pathogenesis of dermatomyositis, a severe inflammatory myopathy. Specifically, the award will fund studies to...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $393,412 to Vanderbilt University to develop engineered cell-based therapies to treat osteoarthritis. The project aims to leverage synthetic biology approaches to create programmable cells that can detect and respond to articular cartilage damage, triggering the upregulation of genes that...
The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $173,880 Project Grant (CFDA 93.846 - Arthritis, Musculoskeletal and Skin Diseases Research) to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System Incorporated. This 5-year longitudinal study will investigate the bidirectional relationship between sleep quality and disease activity in patients with psoriatic arthritis, and explore systemic inflammation as a mediating...
This $715,957 federal Project Grant award was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The award was granted to Northwestern University to conduct research aimed at elucidating the molecular mechanisms by which interferon supports the production and expansion of T peripheral helper (TPH) cells, which are pathologically expanded in systemic lupus...
This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $366,797 to the University of Missouri System to investigate the role of reverse transendothelial migration of neutrophils in the resolution of inflammation. The research aims to provide new knowledge and understanding of neutrophil trafficking during inflammation and the impact...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), will provide $170,101 to Brigham & Women's Hospital Inc. to conduct research on spatial heterogeneity of synovial inflammation in rheumatoid arthritis (RA). The research aims to identify the spatial underpinnings of known RA subtypes and define new spatially-informed RA subtypes using advanced...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $383,570 to Temple University to conduct research on interleukin-36 (IL-36) cytokine activation and inactivation mechanisms. The project aims to improve understanding of IL-36 functions and their role in inflammatory conditions, such as atopic dermatitis, psoriasis, and skin infections,...
This $548,828 Project Grant was awarded on September 21, 2023 by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant was awarded to Knoubis Bio Inc., a for-profit organization based in California, to support research on a non-immunosuppressive disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis. The project aims to develop a new therapeutic approach...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $163,514 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to Brigham & Women's Hospital Inc. The grant supports research to biochemically define a new G protein-coupled receptor (GPCR) signaling pathway with relevance to chemokine receptor signaling, particularly the CXCR3 receptor expressed on activated T cells. The project aims to discover how...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), which falls under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $735,460 to Vanderbilt University Medical Center (VUMC) for a research project titled "Immune Cell Contributions to Inflammatory Arthritis." The project aims to investigate the mechanisms by which decreases in anti-inflammatory IL-10-producing B regulatory (Breg) cells and increases in pro-inflammatory IL-6-producing B effector (Beff) cells promote Th17 cell inflammation and the development of psoriatic arthritis (PsA), a debilitating form of inflammatory arthritis. The research will utilize the KLK6+ mouse model of PsA and samples from PsA patients to elucidate the cellular and molecular pathways underlying B cell-T cell interactions that drive PsA pathogenesis. The award period is from April 10, 2025, to March 31, 2030, and the findings may lead to a paradigm shift in understanding PsA and the repurposing of existing FDA-approved drugs for treating this condition.